ENSG00000233276


Homo sapiens

Features
Gene ID: ENSG00000233276
  
Biological name :GPX1
  
Synonyms : glutathione peroxidase 1 / GPX1 / P07203
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49357171
Gene end: 49358600
  
Corresponding Affymetrix probe sets: 200736_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391316
Ensembl peptide - ENSP00000493593
Ensembl peptide - ENSP00000495108
Ensembl peptide - ENSP00000495001
Ensembl peptide - ENSP00000407375
Ensembl peptide - ENSP00000478837
NCBI entrez gene - 2876     See in Manteia.
OMIM - 138320
RefSeq - NM_000581
RefSeq - NM_001329503
RefSeq - NM_201397
RefSeq Peptide - NP_958799
RefSeq Peptide - NP_000572
RefSeq Peptide - NP_001316432
swissprot - Q7L4Q3
swissprot - P07203
swissprot - A0A087WUQ6
Ensembl - ENSG00000233276
  
Related genetic diseases (OMIM): 614164 - Hemolytic anemia due to glutathione peroxidase deficiency, 614164
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPX1ENSGALG00000028204Gallus gallus
 Gpx1ENSMUSG00000063856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX2 / P18283 / glutathione peroxidase 2ENSG0000017615363
GPX5 / O75715 / glutathione peroxidase 5ENSG0000022458645
GPX3 / P22352 / glutathione peroxidase 3ENSG0000021144541
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870438
GPX7 / Q96SL4 / glutathione peroxidase 7ENSG0000011615732
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746831
GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)ENSG0000016429428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001885 endothelial cell development IEA
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
 biological_processGO:0006195 purine nucleotide catabolic process TAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0009410 response to xenobiotic stimulus IEA
 biological_processGO:0009609 response to symbiotic bacterium IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009650 UV protection IMP
 biological_processGO:0010269 response to selenium ion IMP
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0018158 protein oxidation IEA
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0034599 cellular response to oxidative stress NAS
 biological_processGO:0040029 regulation of gene expression, epigenetic IDA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0042744 hydrogen peroxide catabolic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045454 cell redox homeostasis IDA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IDA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902905 positive regulation of supramolecular fiber organization ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097413 Lewy body IDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
Purine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0003265 Neonatal hyperbilirubinemia 
Show

 HP:0004863 compensated hemolytic anemia 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000233276 GPX1 / P07203 / glutathione peroxidase 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr