ENSG00000211445


Homo sapiens

Features
Gene ID: ENSG00000211445
  
Biological name :GPX3
  
Synonyms : glutathione peroxidase 3 / GPX3 / P22352
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.1
Gene start: 151020438
Gene end: 151028993
  
Corresponding Affymetrix probe sets: 201348_at (Human Genome U133 Plus 2.0 Array)   214091_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429314
Ensembl peptide - ENSP00000429709
Ensembl peptide - ENSP00000484258
Ensembl peptide - ENSP00000483660
Ensembl peptide - ENSP00000430743
Ensembl peptide - ENSP00000430508
Ensembl peptide - ENSP00000373477
Ensembl peptide - ENSP00000427873
NCBI entrez gene - 2878     See in Manteia.
OMIM - 138321
RefSeq - NM_002084
RefSeq Peptide - NP_002075
swissprot - A0A182DWH9
swissprot - A0A087X1J7
swissprot - H0YBE4
swissprot - H0YC19
swissprot - P22352
swissprot - E5RG32
swissprot - Q6NXQ3
swissprot - A0A182DWI0
Ensembl - ENSG00000211445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx3ENSDARG00000043342Danio rerio
 GPX3ENSGALG00000004521Gallus gallus
 Gpx3ENSMUSG00000018339Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870469
GPX5 / O75715 / glutathione peroxidase 5ENSG0000022458669
GPX1 / P07203 / glutathione peroxidase 1ENSG0000023327637
GPX2 / P18283 / glutathione peroxidase 2ENSG0000017615334
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746826
GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)ENSG0000016429424
GPX7 / Q96SL4 / glutathione peroxidase 7ENSG0000011615724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0006982 response to lipid hydroperoxide TAS
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0008430 selenium binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000211445 GPX3 / P22352 / glutathione peroxidase 3  / complex






 

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