ENSG00000164294


Homo sapiens

Features
Gene ID: ENSG00000164294
  
Biological name :GPX8
  
Synonyms : glutathione peroxidase 8 (putative) / GPX8 / Q8TED1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55160118
Gene end: 55167071
  
Corresponding Affymetrix probe sets: 227628_at (Human Genome U133 Plus 2.0 Array)   228141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427466
Ensembl peptide - ENSP00000296734
Ensembl peptide - ENSP00000423822
NCBI entrez gene - 493869     See in Manteia.
OMIM - 617172
RefSeq - XM_006714631
RefSeq - NM_001008397
RefSeq - NM_001306197
RefSeq - NM_001306198
RefSeq - NM_001306201
RefSeq Peptide - NP_001293127
RefSeq Peptide - NP_001293130
RefSeq Peptide - NP_001293126
RefSeq Peptide - NP_001008398
swissprot - J3KNB5
swissprot - E7ETY7
swissprot - Q8TED1
Ensembl - ENSG00000164294
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx8ENSDARG00000013302Danio rerio
 GPX8ENSGALG00000026704Gallus gallus
 Gpx8ENSMUSG00000021760Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX7 / Q96SL4 / glutathione peroxidase 7ENSG0000011615745
GPX5 / O75715 / glutathione peroxidase 5ENSG0000022458630
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746830
GPX1 / P07203 / glutathione peroxidase 1ENSG0000023327627
GPX2 / P18283 / glutathione peroxidase 2ENSG0000017615326
GPX3 / P22352 / glutathione peroxidase 3ENSG0000021144526
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR013376  Glutathione peroxidase Gpx7, putative
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197930 ERO1A / Q96HE7 / endoplasmic reticulum oxidoreductase 1 alpha  / complex
 ENSG00000185624 P4HB / P07237 / prolyl 4-hydroxylase subunit beta  / reaction






 

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