ENSG00000197930


Homo sapiens

Features
Gene ID: ENSG00000197930
  
Biological name :ERO1A
  
Synonyms : endoplasmic reticulum oxidoreductase 1 alpha / ERO1A / Q96HE7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q22.1
Gene start: 52639916
Gene end: 52695900
  
Corresponding Affymetrix probe sets: 218498_s_at (Human Genome U133 Plus 2.0 Array)   222646_s_at (Human Genome U133 Plus 2.0 Array)   225750_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452269
Ensembl peptide - ENSP00000487101
Ensembl peptide - ENSP00000379042
Ensembl peptide - ENSP00000450655
Ensembl peptide - ENSP00000451204
Ensembl peptide - ENSP00000452020
Ensembl peptide - ENSP00000452093
NCBI entrez gene - 30001     See in Manteia.
OMIM - 615435
RefSeq - XM_011536684
RefSeq - NM_014584
RefSeq Peptide - NP_055399
swissprot - G3V503
swissprot - G3V5B3
swissprot - G3V2H0
swissprot - Q96HE7
swissprot - G3V3E6
Ensembl - ENSG00000197930
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ero1aENSDARG00000015228Danio rerio
 ERO1AENSGALG00000012404Gallus gallus
 Ero1lENSMUSG00000021831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERO1B / Q86YB8 / endoplasmic reticulum oxidoreductase 1 betaENSG0000008661960


Protein motifs (from Interpro)
Interpro ID Name
 IPR007266  Endoplasmic reticulum oxidoreductin 1
 IPR037192  ERO1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009266 response to temperature stimulus TAS
 biological_processGO:0010260 animal organ senescence IEA
 biological_processGO:0019471 4-hydroxyproline metabolic process IEA
 biological_processGO:0022417 protein maturation by protein folding IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0034975 protein folding in endoplasmic reticulum IBA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0015036 disulfide oxidoreductase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA


Pathways (from Reactome)
Pathway description
Insulin processing
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164294 GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)  / complex
 ENSG00000116157 GPX7 / Q96SL4 / glutathione peroxidase 7  / complex
 ENSG00000254647 INS / P01308 / insulin  / reaction






 

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