ENSMUSG00000021831


Mus musculus

Features
Gene ID: ENSMUSG00000021831
  
Biological name :Ero1l
  
Synonyms : Ero1l / ERO1-like protein alpha / Q8R180
  
Possible biological names infered from orthology : endoplasmic reticulum oxidoreductase 1 alpha / ERO1A / Q96HE7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 45283087
Gene end: 45318771
  
Corresponding Affymetrix probe sets: 10419198 (MoGene1.0st)   1419029_at (Mouse Genome 430 2.0 Array)   1419030_at (Mouse Genome 430 2.0 Array)   1449324_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022378
Ensembl peptide - ENSMUSP00000153844
Ensembl peptide - ENSMUSP00000154411
NCBI entrez gene - 50527     See in Manteia.
MGI - MGI:1354385
RefSeq - NM_015774
RefSeq Peptide - NP_056589
swissprot - Q4FK57
swissprot - Q8R180
Ensembl - ENSMUSG00000021831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ero1aENSDARG00000015228Danio rerio
 ERO1AENSGALG00000012404Gallus gallus
 ERO1AENSG00000197930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ero1lb / Q8R2E9 / ERO1-like protein beta / ERO1B* / Q86YB8* / endoplasmic reticulum oxidoreductase 1 beta*ENSMUSG0000005706959


Protein motifs (from Interpro)
Interpro ID Name
 IPR007266  Endoplasmic reticulum oxidoreductin 1
 IPR037192  ERO1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding ISO
 biological_processGO:0006464 cellular protein modification process IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010260 animal organ senescence IEA
 biological_processGO:0019471 4-hydroxyproline metabolic process IGI
 biological_processGO:0022417 protein maturation by protein folding IGI
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0034975 protein folding in endoplasmic reticulum IBA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0045454 cell redox homeostasis IGI
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISO
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity ISO
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA


Pathways (from Reactome)
Pathway description
Insulin processing
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021760 Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*  / complex
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / reaction
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / reaction
 ENSMUSG00000028597 Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*  / complex






 

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