ENSMUSG00000057069


Mus musculus

Features
Gene ID: ENSMUSG00000057069
  
Biological name :Ero1lb
  
Synonyms : Ero1lb / ERO1-like protein beta / Q8R2E9
  
Possible biological names infered from orthology : endoplasmic reticulum oxidoreductase 1 beta / ERO1B / Q86YB8
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 12565874
Gene end: 12611396
  
Corresponding Affymetrix probe sets: 10403558 (MoGene1.0st)   1425705_a_at (Mouse Genome 430 2.0 Array)   1434714_at (Mouse Genome 430 2.0 Array)   1449948_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152393
Ensembl peptide - ENSMUSP00000152543
Ensembl peptide - ENSMUSP00000071864
NCBI entrez gene - 67475     See in Manteia.
MGI - MGI:1914725
RefSeq - XM_006516730
RefSeq - XM_006516731
RefSeq - XM_006516732
RefSeq - NM_026184
RefSeq Peptide - NP_080460
swissprot - Q8R2E9
swissprot - A0A1Y7VJM4
swissprot - A0A1Y7VNF4
Ensembl - ENSMUSG00000057069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ero1bENSDARG00000103915Danio rerio
 ERO1BENSGALG00000040000Gallus gallus
 ERO1BENSG00000086619Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ero1l / Q8R180 / ERO1-like protein alpha / ERO1A* / Q96HE7* / endoplasmic reticulum oxidoreductase 1 alpha*ENSMUSG0000002183159


Protein motifs (from Interpro)
Interpro ID Name
 IPR007266  Endoplasmic reticulum oxidoreductin 1
 IPR037192  ERO1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IBA
 biological_processGO:0019471 4-hydroxyproline metabolic process IGI
 biological_processGO:0022417 protein maturation by protein folding IMP
 biological_processGO:0030070 insulin processing IMP
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0034975 protein folding in endoplasmic reticulum IBA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045454 cell redox homeostasis IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA


Pathways (from Reactome)
Pathway description
Insulin processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lbGt(P077G11)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lbGt(P077G11)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lbGt(P077G11)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lbGt(P077G11)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lb+,Ins2Akita/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ero1lbGt(P077G11)Wrst/Ero1lbGt(P077G11)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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