ENSMUSG00000035804


Mus musculus

Features
Gene ID: ENSMUSG00000035804
  
Biological name :Ins1
  
Synonyms : Ins1 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / P01325
  
Possible biological names infered from orthology : INS / insulin / P01308
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 52264323
Gene end: 52265456
  
Corresponding Affymetrix probe sets: 10463906 (MoGene1.0st)   1422447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049095
NCBI entrez gene - 16333     See in Manteia.
MGI - MGI:96572
RefSeq - NM_008386
RefSeq Peptide - NP_032412
swissprot - P01325
Ensembl - ENSMUSG00000035804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insENSDARG00000035350Danio rerio
 insbENSDARG00000034610Danio rerio
 P67970ENSGALG00000006552Gallus gallus
 INSENSG00000254647Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*ENSMUSG0000000021590
AC013548.1 / IGF2* / insulin like growth factor 2*ENSMUSG0000011530213


Protein motifs (from Interpro)
Interpro ID Name
 IPR004825  Insulin
 IPR016179  Insulin-like
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0051591 response to cAMP IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Umodtm1Xrw

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Umodtm1Xrw

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0002869 increased insulin autoantibody level "elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002870 decreased insulin autoantibody level "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja
Genetic Background: NOD.129S2-Ins1tm1Jja

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Tg(Ins2*Y16A)1Ell/0
Genetic Background: NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1.1Mnt/Ins2tm1.1Mnt
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014109 increased pancreatic alpha cell proliferation "increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [MGI:Anna]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014122 decreased pancreatic islet cell apoptosis "decrease in the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0030589 increased pancreatic alpha cell mass "greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000021831 Ero1l / Q8R180 / ERO1-like protein alpha / ERO1A* / Q96HE7* / endoplasmic reticulum oxidoreductase 1 alpha*  / reaction
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction






 

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