ENSDARG00000034610


Danio rerio

Features
Gene ID: ENSDARG00000034610
  
Biological name :insb
  
Synonyms : insb / preproinsulin b
  
Possible biological names infered from orthology : AC013548.1 / F8WCM5 / IGF2 / INS / Ins1 / Ins2 / INS-IGF2 / INS-IGF2 readthrough / insulin / Insulin-1 Insulin-1 B chain Insulin-1 A chain / Insulin-2 Insulin-2 B chain Insulin-2 A chain / insulin like growth factor 2 / P01308 / P01325 / P01326
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 28563081
Gene end: 28568152
  
Corresponding Affymetrix probe sets: Dr.19722.1.A1_at (Zebrafish Array)   NM_001039064_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000142147
Ensembl peptide - ENSDARP00000149516
Ensembl peptide - ENSDARP00000110399
Ensembl peptide - ENSDARP00000115146
Ensembl peptide - ENSDARP00000137730
NCBI entrez gene - 566735     See in Manteia.
RefSeq - NM_001039064
RefSeq Peptide - NP_001034153
swissprot - A0A140LFX1
swissprot - F1QAE3
swissprot - Q2QAJ9
ZFIN ID - ZDB-GENE-040113-2
Ensembl - ENSDARG00000034610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P67970ENSGALG00000006552Gallus gallus
 F8WCM5ENSG00000129965Homo sapiens
 IGF2ENSG00000284779Homo sapiens
 INSENSG00000254647Homo sapiens
 AC013548.1ENSMUSG00000115302Mus musculus
 Ins1ENSMUSG00000035804Mus musculus
 Ins2ENSMUSG00000000215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...ENSDARG0000003535028


Protein motifs (from Interpro)
Interpro ID Name
 IPR004825  Insulin
 IPR016179  Insulin-like
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Insulin processing
COPI-mediated anterograde transport
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism malformed , abnormal
whole organism decreased life span , abnormal
whole organism physical object quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011948 insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000002013 grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000035350 ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...  / reaction / complex
 ENSDARG00000071524 insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000034610 insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...  / reaction / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000035308 grb10b / growth factor receptor-bound protein 10b / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction






 

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