ENSDARG00000035350


Danio rerio

Features
Gene ID: ENSDARG00000035350
  
Biological name :ins
  
Synonyms : ins / O73727 / preproinsulin
  
Possible biological names infered from orthology : AC013548.1 / F8WCM5 / IGF2 / Ins1 / Ins2 / INS-IGF2 / INS-IGF2 readthrough / insulin / Insulin-1 Insulin-1 B chain Insulin-1 A chain / Insulin-2 Insulin-2 B chain Insulin-2 A chain / insulin like growth factor 2 / P01308 / P01325 / P01326
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 37854685
Gene end: 37857696
  
Corresponding Affymetrix probe sets: Dr.11838.1.S1_at (Zebrafish Array)   NM_131056_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000153651
Ensembl peptide - ENSDARP00000051221
NCBI entrez gene - 30262     See in Manteia.
RefSeq - NM_131056
RefSeq Peptide - NP_571131
swissprot - B2GSI0
swissprot - O73727
ZFIN ID - ZDB-GENE-980526-110
Ensembl - ENSDARG00000035350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P67970ENSGALG00000006552Gallus gallus
 F8WCM5ENSG00000129965Homo sapiens
 IGF2ENSG00000284779Homo sapiens
 INSENSG00000254647Homo sapiens
 AC013548.1ENSMUSG00000115302Mus musculus
 Ins1ENSMUSG00000035804Mus musculus
 Ins2ENSMUSG00000000215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...ENSDARG0000003461042


Protein motifs (from Interpro)
Interpro ID Name
 IPR004825  Insulin
 IPR016179  Insulin-like
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031667 response to nutrient levels IDA
 biological_processGO:2000228 positive regulation of pancreatic A cell differentiation IMP
 biological_processGO:2000252 negative regulation of feeding behavior IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Insulin processing
COPI-mediated anterograde transport
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm increased amount , abnormal
endoderm decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0005147 regenerating tissue regenerating tissue pancreatic B cell increased amount , abnormal
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 ZFA:0005754 primary islet primary islet pancreatic B cell decreased amount , abnormal
primary islet increased amount , abnormal
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 ZFA:0009101 insulin secreting cell insulin secreting cell increased amount , abnormal
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 ZFA:0009102 pancreatic B cell pancreatic B cell increased amount , abnormal
pancreatic B cell increased distribution , abnormal
pancreatic B cell increased area , abnormal
pancreatic B cell regeneration increased occurrence , abnormal
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 ZFA:0009103 glucagon secreting cell glucagon secreting cell decreased amount , abnormal
Show

 ZFA:0009104 pancreatic A cell pancreatic A cell decreased amount , abnormal
pancreatic A cell regeneration decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011948 insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex / reaction
 ENSDARG00000002013 grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000034610 insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...  / complex / reaction
 ENSDARG00000035350 ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...  / complex / reaction
 ENSDARG00000071524 insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / reaction / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000035308 grb10b / growth factor receptor-bound protein 10b / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / reaction / complex






 

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