ENSDARG00000011948


Danio rerio

Features
Gene ID: ENSDARG00000011948
  
Biological name :insra
  
Synonyms : insra / insulin receptor a
  
Possible biological names infered from orthology : INSR / insulin receptor / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213 / P15208
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37544951
Gene end: 37632896
  
Corresponding Affymetrix probe sets: Dr.16387.1.A1_at (Zebrafish Array)   Dr.16791.1.S1_at (Zebrafish Array)   Dr.20988.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000023951
NCBI entrez gene - 245699     See in Manteia.
RefSeq - NM_001142672
RefSeq Peptide - NP_001136144
swissprot - F1QNX5
ZFIN ID - ZDB-GENE-020503-3
Ensembl - ENSDARG00000011948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSRENSGALG00000040758Gallus gallus
 INSRENSG00000171105Homo sapiens
 InsrENSMUSG00000005534Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152476
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000002742355
igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000003443454
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG0000004286116
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851115
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458615
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG0000009583314
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722814
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989714
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621414
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069314
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383013
ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *ENSDARG0000007852313
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869513
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517613
ror2 / receptor tyrosine kinase-like orphan receptor 2 / Q01974* / Q9Z138*ENSDARG0000007622712
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG0000008719712
ptk7a / protein tyrosine kinase 7a / PTK7* / Q13308* / Q8BKG3* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSDARG0000001186311
musk / muscle, skeletal, receptor tyrosine kinase / Q61006* / O15146* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSDARG000000987643
LT631676.1ENSDARG000001117431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048589 developmental growth IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA


Pathways (from Reactome)
Pathway description
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary deformed , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased size , abnormal
Show

 ZFA:0000128 midbrain midbrain decreased size , abnormal
Show

 ZFA:0000152 retina retina tissue regeneration process quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0005147 regenerating tissue regenerating tissue Muller cell decreased amount , abnormal
Show

 ZFA:0009280 Muller cell Muller cell cell proliferation decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011948 insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex
 ENSDARG00000035350 ins / O73727 / preproinsulin / Ins1* / IGF2* / Ins2* / F8WCM5* / P01326* / P01325* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / I...  / complex / reaction
 ENSDARG00000034610 insb / preproinsulin b / INS* / IGF2* / Ins1* / Ins2* / P01325* / F8WCM5* / P01326* / P01308* / insulin* / INS-IGF2* / AC013548.1* / INS-IGF2 readthrough* / insulin like growth factor 2* / ...  / complex / reaction
 ENSDARG00000071524 insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*  / complex
 ENSDARG00000002013 grb10a / growth factor receptor-bound protein 10a / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000035308 grb10b / growth factor receptor-bound protein 10b / GRB10* / Q60760* / Q13322* / growth factor receptor bound protein 10*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr