ENSDARG00000076227


Danio rerio

Features
Gene ID: ENSDARG00000076227
  
Biological name :ror2
  
Synonyms : receptor tyrosine kinase-like orphan receptor 2 / ror2
  
Possible biological names infered from orthology : Q01974 / Q9Z138
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 5268054
Gene end: 5407509
  
Corresponding Affymetrix probe sets: Dr.16109.1.S1_at (Zebrafish Array)   XM_684589_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000101065
NCBI entrez gene - 561183     See in Manteia.
RefSeq - XM_021472213
RefSeq - XM_684589
swissprot - E7FCE4
ZFIN ID - ZDB-GENE-060427-5
Ensembl - ENSDARG00000076227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROR2ENSGALG00000015208Gallus gallus
 ROR2ENSG00000169071Homo sapiens
 Ror2ENSMUSG00000021464Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517653
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851119
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621418
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989718
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000002742318
igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000003443418
insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000001194818
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152417
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458617
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722817
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG0000004286116
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG0000009583315
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383015
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069315
ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *ENSDARG0000007852314
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869514
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG0000008719713
ptk7a / protein tyrosine kinase 7a / PTK7* / Q13308* / Q8BKG3* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSDARG0000001186313
musk / muscle, skeletal, receptor tyrosine kinase / Q61006* / O15146* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSDARG000000987644
LT631676.1ENSDARG000001117430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR016247  Tyrosine-protein kinase, receptor ROR
 IPR018056  Kringle, conserved site
 IPR020067  Frizzled domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0060027 convergent extension involved in gastrulation IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000016 ectoderm ectoderm cell shape , abnormal
ectoderm cell orientation ectoderm , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000135 notochord notochord cell shape , abnormal
notochord cell orientation notochord , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr