ENSDARG00000078523


Danio rerio

Features
Gene ID: ENSDARG00000078523
  
Biological name :ddr1
  
Synonyms : ddr1 / discoidin domain receptor tyrosine kinase 1
  
Possible biological names infered from orthology : Epithelial discoidin domain-containing receptor 1 / Q03146 / Q08345
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 21547583
Gene end: 21620949
  
Corresponding Affymetrix probe sets: Dr.1094.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000146875
Ensembl peptide - ENSDARP00000152067
Ensembl peptide - ENSDARP00000150745
Ensembl peptide - ENSDARP00000102505
Ensembl peptide - ENSDARP00000137950
NCBI entrez gene - 100007346     See in Manteia.
RefSeq - XM_009292273
swissprot - E7F3X9
swissprot - A0A0R4ISN8
ZFIN ID - ZDB-GENE-060323-2
Ensembl - ENSDARG00000078523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDR1ENSG00000204580Homo sapiens
 Ddr1ENSMUSG00000003534Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069348
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383045
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869545
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722819
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989719
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851119
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152418
insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000001194818
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458618
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621418
igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000003443417
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000002742317
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517615
ptk7a / protein tyrosine kinase 7a / PTK7* / Q13308* / Q8BKG3* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSDARG0000001186314
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG0000008719714
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG0000004286114
ror2 / receptor tyrosine kinase-like orphan receptor 2 / Q01974* / Q9Z138*ENSDARG0000007622713
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG0000009583313
musk / muscle, skeletal, receptor tyrosine kinase / Q61006* / O15146* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSDARG000000987644
LT631676.1ENSDARG000001117431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029553  Epithelial discoidin domain-containing receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0038062 protein tyrosine kinase collagen receptor activity IEA


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000078523 ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *  / complex






 

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