ENSMUSG00000021760


Mus musculus

Features
Gene ID: ENSMUSG00000021760
  
Biological name :Gpx8
  
Synonyms : Gpx8 / Probable glutathione peroxidase 8 / Q9D7B7
  
Possible biological names infered from orthology : glutathione peroxidase 8 (putative) / Q8TED1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 113042759
Gene end: 113046386
  
Corresponding Affymetrix probe sets: 10412207 (MoGene1.0st)   1424099_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022282
NCBI entrez gene - 69590     See in Manteia.
MGI - MGI:1916840
RefSeq - NM_027127
RefSeq - XM_017315596
RefSeq Peptide - NP_081403
swissprot - Q9D7B7
Ensembl - ENSMUSG00000021760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx8ENSDARG00000013302Danio rerio
 GPX8ENSGALG00000026704Gallus gallus
 GPX8ENSG00000164294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*ENSMUSG0000002859742
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570630
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434127
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*ENSMUSG0000006385625
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*ENSMUSG0000000434424
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*ENSMUSG0000001833924
Gpx2 / glutathione peroxidase 2 / P18283*ENSMUSG0000004280824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR013376  Glutathione peroxidase Gpx7, putative
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004601 peroxidase activity ISO
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Alg2tm1Lex/Alg2tm1Lex
Genetic Background: B6;129S5-Alg2tm1Lex/Mmucd

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Alg2tm1Lex/Alg2tm1Lex
Genetic Background: B6;129S5-Alg2tm1Lex/Mmucd

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Alg2tm1Lex/Alg2tm1Lex
Genetic Background: B6;129S5-Alg2tm1Lex/Mmucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021831 Ero1l / Q8R180 / ERO1-like protein alpha / ERO1A* / Q96HE7* / endoplasmic reticulum oxidoreductase 1 alpha*  / complex
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr