Manteia - Molecule gene

ENSMUSG00000075706

Mus musculus

Features

Gene ID:	ENSMUSG00000075706

Biological name :	Gpx4

Synonyms :	Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

Possible biological names infered from orthology :	glutathione peroxidase 4 / P36969

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	C1
Gene start:	80047166
Gene end:	80056439

Corresponding Affymetrix probe sets:	10363000 (MoGene1.0st) 10364675 (MoGene1.0st) 1451695_a_at (Mouse Genome 430 2.0 Array) 1456193_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000094863 Ensembl peptide - ENSMUSP00000101011 Ensembl peptide - ENSMUSP00000138186 NCBI entrez gene - 625249 See in Manteia. MGI - MGI:104767 RefSeq - NM_001037741 RefSeq - NM_008162 RefSeq Peptide - NP_001032830 RefSeq Peptide - NP_032188 swissprot - S4R1E5 swissprot - O70325 swissprot - Q76LV0 swissprot - F7A8H6 Ensembl - ENSMUSG00000075706

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gpx4b	ENSDARG00000076836	Danio rerio
GPX4	ENSGALG00000002595	Gallus gallus
GPX4	ENSG00000167468	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*	ENSMUSG00000028597	28
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*	ENSMUSG00000021760	25
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*	ENSMUSG00000063856	25
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*	ENSMUSG00000018339	23
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*	ENSMUSG00000004341	22
Gpx2 / glutathione peroxidase 2 / P18283*	ENSMUSG00000042808	21
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*	ENSMUSG00000004344	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000889	Glutathione peroxidase
IPR029759	Glutathione peroxidase active site
IPR029760	Glutathione peroxidase conserved site
IPR036249	Thioredoxin-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006325	chromatin organization	IDA
biological_process	GO:0006979	response to oxidative stress	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0051258	protein polymerization	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0098869	cellular oxidant detoxification	IEA
biological_process	GO:0110076	negative regulation of ferroptosis	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005635	nuclear envelope	IDA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005743	mitochondrial inner membrane	IDA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0004601	peroxidase activity	IEA
molecular_function	GO:0004602	glutathione peroxidase activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	IEA

Pathways (from Reactome)

Pathway description

Synthesis of 12-eicosatetraenoic acid derivatives

Synthesis of 15-eicosatetraenoic acid derivatives

Biosynthesis of D-series resolvins

Biosynthesis of E-series 18(S)-resolvins

Biosynthesis of aspirin-triggered D-series resolvins

Biosynthesis of E-series 18(R)-resolvins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000859	abnormal somatosensory cortex morphology	"any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Apob^tm1.1Zc/Apob⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001658	increased mortality induced by gamma-irradiation	"greater sensitivity to doses of ionizing radiation" [J:51834]	Show Allelic Composition: Egr2^tm1.1Jchn/Egr2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0001674	abnormal triploblastic development	"abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr2^tm1.1Jchn/Egr2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001696	failure to gastrulate	"inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]	Show Allelic Composition: Egr2^tm1.1Jchn/Egr2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Gpx4^tm1Yana/Gpx4^tm1Yana Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Gpx4^tm1Yana/Gpx4^tm1Yana Genetic Background: involves: C57BL/6 * CBA
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adam17^tm1.1Bbl/Adam17^tm1.1Bbl Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Adam17^tm1.1Bbl/Adam17^tm1.1Bbl Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr2^tm1.1Jchn/Egr2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0002557	abnormal social/conspecific interaction	"deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0002674	abnormal sperm motility	"anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Glis2^tm1Amj/Glis2^tm1Amj Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0006036	abnormal mitochondrial physiology		Show Allelic Composition: Glis2^tm1Amj/Glis2^tm1Amj Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Hoxd11^tm1Mrc/Hoxd11^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd
MP:0009230	abnormal sperm head morphology	"any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009237	kinked sperm flagellum	"a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009647	decreased fertilization frequency	"he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009687	empty decidua capsularis	"the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009831	abnormal sperm midpiece morphology	"any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009832	abnormal sperm mitochondrial sheath morphology	"any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc Allelic Composition: Gpx4^tm4Marc/Gpx4⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009836	abnormal sperm principal piece morphology	"any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]	Show Allelic Composition: Pklr^slc/Pklr^slc Genetic Background: CBA/NSlc-Pklr^slc
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Glis2^tm1Amj/Glis2^tm1Amj Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011095	complete embryonic lethality between implantation and placentation	"death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Gpx4^tm4Marc/Gpx4^tm4Marc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Egr2^tm1.1Jchn/Egr2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Gpx4^tm2.1Marc/Gpx4^tm2.1Marc Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Gpx4^tm1Yana/Gpx4^tm1Yana Genetic Background: involves: C57BL/6 * CBA
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Gpx4^tm1.1Qra/Gpx4^tm1.1Qra,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr