ENSMUSG00000063856


Mus musculus

Features
Gene ID: ENSMUSG00000063856
  
Biological name :Gpx1
  
Synonyms : Gpx1 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P11352
  
Possible biological names infered from orthology : glutathione peroxidase 1 / P07203
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108338903
Gene end: 108340343
  
Corresponding Affymetrix probe sets: 10588899 (MoGene1.0st)   1460671_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141279
Ensembl peptide - ENSMUSP00000142257
Ensembl peptide - ENSMUSP00000081010
NCBI entrez gene - 14775     See in Manteia.
MGI - MGI:104887
RefSeq - NM_008160
RefSeq - NM_001329527
RefSeq Peptide - NP_001316456
RefSeq Peptide - NP_032186
swissprot - P11352
swissprot - A0A0A6YY34
swissprot - A0A0A6YVV2
Ensembl - ENSMUSG00000063856
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPX1ENSGALG00000028204Gallus gallus
 GPX1ENSG00000233276Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx2 / glutathione peroxidase 2 / P18283*ENSMUSG0000004280860
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434148
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*ENSMUSG0000001833946
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*ENSMUSG0000000434446
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*ENSMUSG0000002859733
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570631
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*ENSMUSG0000002176026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IMP
 biological_processGO:0001659 temperature homeostasis IGI
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IGI
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0009410 response to xenobiotic stimulus IMP
 biological_processGO:0009609 response to symbiotic bacterium IGI
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0010332 response to gamma radiation IGI
 biological_processGO:0014902 myotube differentiation IMP
 biological_processGO:0018158 protein oxidation IMP
 biological_processGO:0033194 response to hydroperoxide IMP
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IMP
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0051450 myoblast proliferation IMP
 biological_processGO:0051702 interaction with symbiont IGI
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IMP
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0097413 Lewy body IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
Purine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,SordC57BL/Lia/SordC57BL/Lia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx2tm2Coh/Gpx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0005035 perianal ulceration "lesion around or near the anus" [cml:Cathy M Lutz , Mouse Genome Informatics Curator, J:71506]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx2tm2Coh/Gpx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Gpx1tm1Mgr/Gpx1tm1Mgr
Genetic Background: involves: 129 * C57BL/6J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0006080 CNS ischemia "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn

 MP:0011592 abnormal catalase activity "anomaly in the ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011603 decreased glutathione peroxidase activity "reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx3tm1Hjco/Gpx3tm1Hjco
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013481 abnormal ileum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [MGI:Anna]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013483 abnormal jejunum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna]
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063856 Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*  / complex






 

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