ENSGALG00000028204


Gallus gallus

Features
Gene ID: ENSGALG00000028204
  
Biological name :GPX1
  
Synonyms : glutathione peroxidase 1 / GPX1
  
Possible biological names infered from orthology : Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203 / P11352
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 2823571
Gene end: 2824313
  
Corresponding Affymetrix probe sets: Gga.1465.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041423
NCBI entrez gene - 100857115     See in Manteia.
RefSeq - NM_001277853
RefSeq Peptide - NP_001264782
swissprot - R4GH86
Ensembl - ENSGALG00000028204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPX1ENSG00000233276Homo sapiens
 Gpx1ENSMUSG00000063856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX2 / glutathione peroxidase 2 / P18283*ENSGALG0000004203152
GPX3 / glutathione peroxidase 3 precursor / GPX5* / GPX6* / P22352* / P46412* / P59796* / Q91WR8* / O75715* / P21765* / glutathione peroxidase 5* / glutathione peroxidase 3* / glutathione ...ENSGALG0000000452131
GPX4 / glutathione peroxidase 4 / O70325* / P36969* / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial *ENSGALG0000000259527
GPX7 / glutathione peroxidase 7 / Q96SL4* / Q99LJ6*ENSGALG0000001063320
GPX8 / glutathione peroxidase 8 (putative) / Q8TED1* / Q9D7B7* / Probable glutathione peroxidase 8 *ENSGALG0000002670418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR012336  Thioredoxin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001885 endothelial cell development IEA
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0009410 response to xenobiotic stimulus IEA
 biological_processGO:0009609 response to symbiotic bacterium IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0018158 protein oxidation IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0051450 myoblast proliferation IEA
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0097413 Lewy body IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
Purine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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