ENSMUSG00000018339


Mus musculus

Features
Gene ID: ENSMUSG00000018339
  
Biological name :Gpx3
  
Synonyms : Glutathione peroxidase 3 / Gpx3 / P46412
  
Possible biological names infered from orthology : P22352
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 54902453
Gene end: 54910377
  
Corresponding Affymetrix probe sets: 10376201 (MoGene1.0st)   1449106_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081011
Ensembl peptide - ENSMUSP00000119882
Ensembl peptide - ENSMUSP00000119165
NCBI entrez gene - 14778     See in Manteia.
MGI - MGI:105102
RefSeq - NM_008161
RefSeq Peptide - NP_032187
swissprot - A0A1C7ZMZ7
swissprot - A0A1C7ZMZ5
swissprot - P46412
Ensembl - ENSMUSG00000018339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx3ENSDARG00000043342Danio rerio
 GPX3ENSGALG00000004521Gallus gallus
 GPX3ENSG00000211445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434166
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*ENSMUSG0000000434465
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*ENSMUSG0000006385641
Gpx2 / glutathione peroxidase 2 / P18283*ENSMUSG0000004280835
Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*ENSMUSG0000002859726
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570625
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*ENSMUSG0000002176023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IDA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0008430 selenium binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0001775 abnormal selenium level "anomalous concentration of this essential trace element, required for glutathione peroxidase and other enzymes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fshrtm1Hht/Fshrtm1Hht
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011603 decreased glutathione peroxidase activity "reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
Show

Allelic Composition: Fshrtm1Hht/Fshrtm1Hht
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,Gpx3tm1Hjco/Gpx3tm1Hjco
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018339 Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*  / complex






 

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