ENSG00000224586


Homo sapiens

Features
Gene ID: ENSG00000224586
  
Biological name :GPX5
  
Synonyms : glutathione peroxidase 5 / GPX5 / O75715
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.1
Gene start: 28525925
Gene end: 28534952
  
Corresponding Affymetrix probe sets: 208028_s_at (Human Genome U133 Plus 2.0 Array)   214648_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392398
Ensembl peptide - ENSP00000419935
NCBI entrez gene - 2880     See in Manteia.
OMIM - 603435
RefSeq - NM_003996
RefSeq - NM_001509
RefSeq Peptide - NP_001500
RefSeq Peptide - NP_003987
swissprot - O75715
swissprot - V9HWN8
Ensembl - ENSG00000224586
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx3ENSDARG00000043342Danio rerio
 GPX3ENSGALG00000004521Gallus gallus
 Gpx5ENSMUSG00000004344Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX3 / P22352 / glutathione peroxidase 3ENSG0000021144570
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870467
GPX1 / P07203 / glutathione peroxidase 1ENSG0000023327642
GPX2 / P18283 / glutathione peroxidase 2ENSG0000017615338
GPX7 / Q96SL4 / glutathione peroxidase 7ENSG0000011615728
GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)ENSG0000016429428
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0097524 sperm plasma membrane IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr