ENSG00000176153


Homo sapiens

Features
Gene ID: ENSG00000176153
  
Biological name :GPX2
  
Synonyms : glutathione peroxidase 2 / GPX2 / P18283
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q23.3
Gene start: 64939152
Gene end: 64942905
  
Corresponding Affymetrix probe sets: 202831_at (Human Genome U133 Plus 2.0 Array)   239595_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451844
Ensembl peptide - ENSP00000478082
Ensembl peptide - ENSP00000374265
Ensembl peptide - ENSP00000450991
Ensembl peptide - ENSP00000451721
NCBI entrez gene - 2877     See in Manteia.
OMIM - 138319
RefSeq - NM_002083
RefSeq Peptide - NP_002074
swissprot - G3V4J6
swissprot - A0A087WTS0
swissprot - P18283
swissprot - H0YJK8
swissprot - G3V323
Ensembl - ENSG00000176153
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx1aENSDARG00000018146Danio rerio
 gpx1bENSDARG00000006207Danio rerio
 GPX2ENSGALG00000042031Gallus gallus
 Gpx2ENSMUSG00000042808Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX1 / P07203 / glutathione peroxidase 1ENSG0000023327667
GPX5 / O75715 / glutathione peroxidase 5ENSG0000022458645
GPX3 / P22352 / glutathione peroxidase 3ENSG0000021144540
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870439
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746829
GPX7 / Q96SL4 / glutathione peroxidase 7ENSG0000011615729
GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)ENSG0000016429428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000176153 GPX2 / P18283 / glutathione peroxidase 2  / complex






 

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