ENSMUSG00000028158


Mus musculus

Features
Gene ID: ENSMUSG00000028158
  
Biological name :Mttp
  
Synonyms : Microsomal triglyceride transfer protein large subunit / Mttp / O08601
  
Possible biological names infered from orthology : microsomal triglyceride transfer protein / P55157
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 138089854
Gene end: 138144968
  
Corresponding Affymetrix probe sets: 10502375 (MoGene1.0st)   1419399_at (Mouse Genome 430 2.0 Array)   1419400_at (Mouse Genome 430 2.0 Array)   1441196_at (Mouse Genome 430 2.0 Array)   1443951_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029805
Ensembl peptide - ENSMUSP00000096179
NCBI entrez gene - 17777     See in Manteia.
MGI - MGI:106926
RefSeq - XM_017319475
RefSeq - NM_001163457
RefSeq - NM_008642
RefSeq - XM_006501102
RefSeq - XM_006501103
RefSeq - XM_017319474
RefSeq Peptide - NP_001156929
RefSeq Peptide - NP_001341980
RefSeq Peptide - NP_001341981
RefSeq Peptide - NP_032668
swissprot - O08601
Ensembl - ENSMUSG00000028158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mttpENSDARG00000008637Danio rerio
 MTTPENSGALG00000035619Gallus gallus
 MTTPENSG00000138823Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001747  Lipid transport protein, N-terminal
 IPR011030  Lipovitellin-phosvitin complex, superhelical domain
 IPR015816  Vitellinogen, beta-sheet N-terminal
 IPR015819  Lipid transport protein, beta-sheet shell


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006497 protein lipidation IDA
 biological_processGO:0006629 lipid metabolic process IDA
 biological_processGO:0006641 triglyceride metabolic process IDA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009306 protein secretion ISO
 biological_processGO:0015914 phospholipid transport ISO
 biological_processGO:0034197 triglyceride transport ISO
 biological_processGO:0034377 plasma lipoprotein particle assembly ISO
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042953 lipoprotein transport IMP
 biological_processGO:0051592 response to calcium ion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0005319 lipid transporter activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005548 phospholipid transporter activity ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
VLDL assembly
Chylomicron assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mttptm1Chan/Mttptm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Mttptm1Sgy/Mttp+
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / complex
 ENSMUSG00000020609 Apob / E9Q414 / Apolipoprotein B-100 Apolipoprotein B-48 / P04114* / apolipoprotein B*  / reaction






 

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