Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000180	abnormal circulating cholesterol level	"anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Apob^tm1Unc/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Insl3^tm1Par/Insl3⁺ Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Insl3^tm1Par/Insl3⁺ Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Apob^tm5Sgy/Apob^tm5Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1.1Zc/Apob⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000184	abnormal circulating HDL cholesterol level	"anomalous concentration in the blood of high denisty lipoprotein; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il4^tm1(CD2)Mmrs/Il4^tm1Lky Genetic Background: involves: 129/Sv * C57BL/6
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Apob^tm1Unc/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm3Sgy/Apob⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Apob^tm1Unc/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm1Mae/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000231	hypertension	"sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Apob^tm3Sgy/Apob^tm3Sgy Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Apob^tm4Sgy/Apob^tm4Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Fgfr1^tm5.1Sor/Fgfr1^tm10.1Sor,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: 129S4.Cg-Fgfr1^tm5.1Sor Fgfr1^tm10.1Sor H2afv^{Tg(Wnt1-cre)11Rth}
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmod3^{Tn(pb-Act-RFP)1.1Zhu}/Lmod3^{Tn(pb-Act-RFP)1.1Zhu} Genetic Background: involves: C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc1a2^tm1.1Pros/Slc1a2^tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Insl3^tm1Par/Insl3⁺ Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dstn^corn1-2J/Dstn^corn1-2J Genetic Background: C57BL/6JSmn-Dstn^corn1-2J/J Allelic Composition: Apob^tm3Sgy/Apob⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Apob^tm4Sgy/Apob^tm4Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm1Mae/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm4Sgy/Apob^tm4Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cebpe^tm1Kgx/Cebpe^tm1Kgx Genetic Background: involves: 129S6/SvEvTac
MP:0002625	left ventricle hypertrophy	"increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1.1Zc/Apob⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Insl3^tm1Par/Insl3⁺ Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0003394	increased cardiac output	"greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0003975	increased circulating VLDL triglyceride level	"higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0004542	impaired acrosome reaction	"abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace^tm1Unc/Ace^tm1Unc,Ace2^tm1Pngr/Ace2^tm1Pngr Genetic Background: involves: 129P2/OlaHsd
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm5Sgy/Apob^tm5Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1.1Zc/Apob⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm3Sgy/Apob⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Apob^tm1Zc/Apob^tm1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1.1Zc Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm4Sgy Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm1Mae/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005201	abnormal retinal pigment epithelium morphology	"anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Fgg^tm1Fjc/Fgg^tm1Fjc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Fgg^tm1Fjc Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Apob^tm3Sgy/Apob⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005339	increased susceptibility to atherosclerosis	"more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Apoe^tm1Unc/Apoe^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0006116	aortic valve calcification	"pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0006117	aortic valve stenosis	"abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apob^tm1Mae/Apob^tm1Mae Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apob^tm1Mae/Apob⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010139	aortitis	"inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0010912	herniated liver	"protrusion of any portion of the liver from its normal anatomical position" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apob^tm4Sgy/Apob^tm4Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Styx^tm1.1Jedi/Styx^tm1.1Jedi Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6) Allelic Composition: Apob^tm4Sgy/Apob^tm4Sgy Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Apob^tm1.1Zc/Apob^tm1.1Zc Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Apob^tm1Zc/Apob^tm1Zc Genetic Background: involves: 129/Sv * C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Apob^tm3Sgy/Apob^tm3Sgy Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0011572	abnormal aorta bulb morphology	"any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [MGI:csmith, PMID:10722531]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011951	increased cardiac stroke volume	"increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0012688	abnormal heart ventricles weight	"abnormal average weight of both the left and right ventricles together" [MPD:Molly]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0013277	abnormal fasted circulating glucose level	"any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0020515	abnormal visceral yolk sac endoderm morphology	"any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]	Show Allelic Composition: Apob^tm3Sgy/Apob^tm3Sgy Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Apob^tm3Sgy/Apob⁺ Genetic Background: either: (involves: 129S7/SvEvBrd * 129/Sv) or (involves: 129S7/SvEvBrd * C57BL/6)

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