ENSMUSG00000037321


Mus musculus

Features
Gene ID: ENSMUSG00000037321
  
Biological name :Tap1
  
Synonyms : P21958 / Tap1 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  
Possible biological names infered from orthology : Q03518 / transporter 1, ATP binding cassette subfamily B member
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34187553
Gene end: 34197225
  
Corresponding Affymetrix probe sets: 10444244 (MoGene1.0st)   1416016_at (Mouse Genome 430 2.0 Array)   1420274_at (Mouse Genome 430 2.0 Array)   1448177_at (Mouse Genome 430 2.0 Array)   1449803_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039264
Ensembl peptide - ENSMUSP00000128401
Ensembl peptide - ENSMUSP00000130189
NCBI entrez gene - 21354     See in Manteia.
MGI - MGI:98483
RefSeq - NM_001161730
RefSeq - NM_013683
RefSeq Peptide - NP_001155202
RefSeq Peptide - NP_038711
swissprot - Q3TBA3
swissprot - P21958
swissprot - F6QHF1
Ensembl - ENSMUSG00000037321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tap1ENSDARG00000079766Danio rerio
 TAP1ENSGALG00000035075Gallus gallus
 TAP1ENSG00000168394Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*ENSMUSG0000002433936
Abcb9 / Q9JJ59 / ATP-binding cassette, sub-family B (MDR/TAP), member 9 / Q9NP78* / ATP binding cassette subfamily B member 9*ENSMUSG0000002940836
Abcb10 / Q9JI39 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / Q9NRK6* / ATP binding cassette subfamily B member 10*ENSMUSG0000003197429
Abcb8 / Q9CXJ4 / ATP-binding cassette, sub-family B (MDR/TAP), member 8 / Q9NUT2* / ATP binding cassette subfamily B member 8*ENSMUSG0000002897327


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR013305  ABC transporter Tap-like
 IPR013306  Antigen peptide transporter 1
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015833 peptide transport ISO
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0046967 cytosol to ER transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0042825 TAP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015433 peptide antigen-transporting ATPase activity EXP
 molecular_functionGO:0015440 peptide-transporting ATPase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0023029 MHC class Ib protein binding IEA
 molecular_functionGO:0042287 MHC protein binding IEA
 molecular_functionGO:0042288 MHC class I protein binding IPI
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046979 TAP2 binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Dckm1Btlr/Dck+
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129-Erap1tm1Nsha Tap1tm1Arp

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0001837 defective assembly of class I molecules "impaired production of major histocompatibility complex class I molecules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0001838 defective intracellular transport of class I molecules "impaired ability to move major histocompatibility complex class I molecules to the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dckm1Btlr/Dck+
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

Allelic Composition: Tap1rose/Tap1rose
Genetic Background: C57BL/6JAnu-Tap1rose/Apb

Allelic Composition: Tap1m2Btlr/Tap1m2Btlr
Genetic Background: C57BL/6J-Tap1m2Btlr

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: B6.129-B2mtm1Jae Tap1tm1Hpl

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: B6.129S2-Tap1tm1Arp/J

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000024339 Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*  / complex
 ENSMUSG00000024308 Tapbp / TAP binding protein / O15533*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction






 

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