ENSMUSG00000031974


Mus musculus

Features
Gene ID: ENSMUSG00000031974
  
Biological name :Abcb10
  
Synonyms : Abcb10 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / Q9JI39
  
Possible biological names infered from orthology : ATP binding cassette subfamily B member 10 / Q9NRK6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 123952459
Gene end: 123983122
  
Corresponding Affymetrix probe sets: 10582626 (MoGene1.0st)   1416402_at (Mouse Genome 430 2.0 Array)   1416403_at (Mouse Genome 430 2.0 Array)   1454265_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075011
NCBI entrez gene - 56199     See in Manteia.
MGI - MGI:1860508
RefSeq - NM_019552
RefSeq - XM_006531201
RefSeq Peptide - NP_062425
swissprot - Q9JI39
Ensembl - ENSMUSG00000031974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb10ENSDARG00000061591Danio rerio
 ABCB10ENSGALG00000011096Gallus gallus
 ABCB10ENSG00000135776Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb8 / Q9CXJ4 / ATP-binding cassette, sub-family B (MDR/TAP), member 8 / Q9NUT2* / ATP binding cassette subfamily B member 8*ENSMUSG0000002897335
Abcb9 / Q9JJ59 / ATP-binding cassette, sub-family B (MDR/TAP), member 9 / Q9NP78* / ATP binding cassette subfamily B member 9*ENSMUSG0000002940834
Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*ENSMUSG0000002433930
Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*ENSMUSG0000003732129


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030260  ATP-binding cassette subfamily B member 10-like
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032592 integral component of mitochondrial membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005215 transporter activity ISA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Mitochondrial ABC transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb10tm1.1Tafu/Abcb10tm1.2Tafu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0013657 abnormal blood cell morphology "any structural anomaly of cells found in the blood" [CL:0000081]
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Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031974 Abcb10 / Q9JI39 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / Q9NRK6* / ATP binding cassette subfamily B member 10*  / complex






 

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