ENSMUSG00000024339


Mus musculus

Features
Gene ID: ENSMUSG00000024339
  
Biological name :Tap2
  
Synonyms : P36371 / Tap2 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  
Possible biological names infered from orthology : AL669918.1 / Q03519 / transporter 2, ATP binding cassette subfamily B member
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34203527
Gene end: 34216321
  
Corresponding Affymetrix probe sets: 10444268 (MoGene1.0st)   1453913_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025197
Ensembl peptide - ENSMUSP00000118916
Ensembl peptide - ENSMUSP00000118700
NCBI entrez gene - 21355     See in Manteia.
MGI - MGI:98484
RefSeq - NM_011530
RefSeq Peptide - NP_035660
swissprot - A0A1B0GXB3
swissprot - A6X8J6
swissprot - P36371
swissprot - Q792S7
Ensembl - ENSMUSG00000024339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tap2aENSDARG00000036787Danio rerio
 tap2tENSDARG00000033446Danio rerio
 TAP2ENSGALG00000029381Gallus gallus
 AL669918.1ENSG00000250264Homo sapiens
 TAP2ENSG00000204267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb9 / Q9JJ59 / ATP-binding cassette, sub-family B (MDR/TAP), member 9 / Q9NP78* / ATP binding cassette subfamily B member 9*ENSMUSG0000002940840
Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*ENSMUSG0000003732138
Abcb10 / Q9JI39 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / Q9NRK6* / ATP binding cassette subfamily B member 10*ENSMUSG0000003197431
Abcb8 / Q9CXJ4 / ATP-binding cassette, sub-family B (MDR/TAP), member 8 / Q9NUT2* / ATP binding cassette subfamily B member 8*ENSMUSG0000002897328


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005293  Antigen peptide transporter 2
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR013305  ABC transporter Tap-like
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity ISO
 biological_processGO:0002237 response to molecule of bacterial origin IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
 biological_processGO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
 biological_processGO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015833 peptide transport IEA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0042886 amide transport IEA
 biological_processGO:0046967 cytosol to ER transport ISO
 biological_processGO:0046968 peptide antigen transport ISO
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0042825 TAP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015433 peptide antigen-transporting ATPase activity ISO
 molecular_functionGO:0015440 peptide-transporting ATPase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0023029 MHC class Ib protein binding ISO
 molecular_functionGO:0042287 MHC protein binding IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0046978 TAP1 binding IPI
 molecular_functionGO:0046980 tapasin binding ISS


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Tap2m1Btlr/Tap2m1Btlr
Genetic Background: C57BL/6J-Tap2m1Btlr

 MP:0001837 defective assembly of class I molecules "impaired production of major histocompatibility complex class I molecules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tap2m1Btlr/Tap2m1Btlr
Genetic Background: C57BL/6J-Tap2m1Btlr

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Tlr3M2Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M2Btlr

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rr29tm1.1Bobh/Rr29+,Shhtm1Chg/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Tap2m2Btlr/Tap2m2Btlr
Genetic Background: C57BL/6J-Tap2m2Btlr

Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Tap2m1Btlr/Tap2m1Btlr
Genetic Background: C57BL/6J-Tap2m1Btlr

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000037321 Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*  / complex
 ENSMUSG00000024308 Tapbp / TAP binding protein / O15533*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction






 

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