ENSMUSG00000024308


Mus musculus

Features
Gene ID: ENSMUSG00000024308
  
Biological name :Tapbp
  
Synonyms : TAP binding protein / Tapbp
  
Possible biological names infered from orthology : O15533
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 33915899
Gene end: 33929288
  
Corresponding Affymetrix probe sets: 10444068 (MoGene1.0st)   1421812_at (Mouse Genome 430 2.0 Array)   1450378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025161
Ensembl peptide - ENSMUSP00000134695
NCBI entrez gene - 21356     See in Manteia.
MGI - MGI:1201689
RefSeq - NM_001025313
RefSeq - NM_009318
RefSeq Peptide - NP_001020484
RefSeq Peptide - NP_033344
swissprot - Q3TCU5
swissprot - G3UZZ2
Ensembl - ENSMUSG00000024308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tapbp.1ENSDARG00000079402Danio rerio
 tapbp.2ENSDARG00000045011Danio rerio
 TAPBPENSGALG00000008022Gallus gallus
 TAPBPENSG00000231925Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VD31 / Tapbpl / Tapasin-related protein / Q9BX59* / TAP binding protein like*ENSMUSG0000003821318


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR008056  Tapasin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002397 MHC class I protein complex assembly IEA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042824 MHC class I peptide loading complex IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0001837 defective assembly of class I molecules "impaired production of major histocompatibility complex class I molecules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Erap1tm1Luc/Erap1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000037321 Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction
 ENSMUSG00000024339 Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*  / reaction






 

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