ENSMUSG00000027438


Mus musculus

Features
Gene ID: ENSMUSG00000027438
  
Biological name :Napb
  
Synonyms : Beta-soluble NSF attachment protein / Napb / P28663
  
Possible biological names infered from orthology : NSF attachment protein beta / Q9H115
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 148693985
Gene end: 148732467
  
Corresponding Affymetrix probe sets: 10488387 (MoGene1.0st)   1423172_at (Mouse Genome 430 2.0 Array)   1423173_at (Mouse Genome 430 2.0 Array)   1427470_s_at (Mouse Genome 430 2.0 Array)   1444234_at (Mouse Genome 430 2.0 Array)   1450888_at (Mouse Genome 430 2.0 Array)   1452444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120979
Ensembl peptide - ENSMUSP00000028926
NCBI entrez gene - 17957     See in Manteia.
MGI - MGI:104562
RefSeq - NM_019632
RefSeq - XM_011239346
RefSeq Peptide - NP_062606
swissprot - D6RHL2
swissprot - P28663
Ensembl - ENSMUSG00000027438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 napbaENSDARG00000013669Danio rerio
 napbbENSDARG00000069101Danio rerio
 NAPBENSGALG00000008313Gallus gallus
 NAPBENSG00000125814Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*ENSMUSG0000000602482


Protein motifs (from Interpro)
Interpro ID Name
 IPR000744  NSF attachment protein
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0010807 regulation of synaptic vesicle priming IGI
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IGI
 biological_processGO:0035494 SNARE complex disassembly IGI
 biological_processGO:0048488 synaptic vesicle endocytosis IC
 biological_processGO:0061025 membrane fusion IBA
 cellular_componentGO:0005774 vacuolar membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
 molecular_functionGO:0005483 soluble NSF attachment protein activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IDA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Napahyh/Napahyh,Napbtm1Rhee/Napbtm1Rhee
Genetic Background: involves: C57BL/10J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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