ENSG00000118640


Homo sapiens

Features
Gene ID: ENSG00000118640
  
Biological name :VAMP8
  
Synonyms : Q9BV40 / VAMP8 / vesicle associated membrane protein 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p11.2
Gene start: 85561562
Gene end: 85582031
  
Corresponding Affymetrix probe sets: 202546_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263864
Ensembl peptide - ENSP00000407984
Ensembl peptide - ENSP00000387094
NCBI entrez gene - 8673     See in Manteia.
OMIM - 603177
RefSeq - NM_003761
RefSeq - XM_017005170
RefSeq Peptide - NP_003752
swissprot - C9JXZ5
swissprot - B8ZZT4
swissprot - Q9BV40
Ensembl - ENSG00000118640
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vamp8ENSDARG00000024116Danio rerio
 Vamp8ENSMUSG00000050732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAMP2 / P63027 / vesicle associated membrane protein 2ENSG0000022020533
VAMP1 / P23763 / vesicle associated membrane protein 1ENSG0000013919033
AC129492.3ENSG0000026362033
VAMP3 / Q15836 / vesicle associated membrane protein 3ENSG0000004924530
VAMP4 / O75379 / vesicle associated membrane protein 4ENSG0000011753325


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006892 post-Golgi vesicle-mediated transport TAS
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016240 autophagosome membrane docking IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046718 viral entry into host cell IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070254 mucus secretion IMP
 biological_processGO:0097352 autophagosome maturation IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IDA
 biological_processGO:1903531 negative regulation of secretion by cell IDA
 biological_processGO:1903595 positive regulation of histamine secretion by mast cell IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0030667 secretory granule membrane IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031201 SNARE complex IDA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0035577 azurophil granule membrane IDA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0098594 mucin granule IDA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019869 chloride channel inhibitor activity IDA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092531 O00161 / SNAP23 / synaptosome associated protein 23  / complex / reaction
 ENSG00000073921 PICALM / Q13492 / phosphatidylinositol binding clathrin assembly protein  / reaction / complex
 ENSG00000103496 STX4 / Q12846 / syntaxin 4  / complex / reaction






 

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