ENSMUSG00000038116


Mus musculus

Features
Gene ID: ENSMUSG00000038116
  
Biological name :Phf20
  
Synonyms : PHD finger protein 20 / Phf20 / Q8BLG0
  
Possible biological names infered from orthology : Q9BVI0
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 156196466
Gene end: 156309952
  
Corresponding Affymetrix probe sets: 10477815 (MoGene1.0st)   1426961_at (Mouse Genome 430 2.0 Array)   1426962_at (Mouse Genome 430 2.0 Array)   1452258_at (Mouse Genome 430 2.0 Array)   1452259_at (Mouse Genome 430 2.0 Array)   1458017_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043138
Ensembl peptide - ENSMUSP00000119756
NCBI entrez gene - 228829     See in Manteia.
MGI - MGI:2444148
RefSeq - XM_017317827
RefSeq - NM_172674
RefSeq - XM_006499338
RefSeq - XM_006499339
RefSeq Peptide - NP_766262
swissprot - A2AV92
swissprot - Q8BLG0
Ensembl - ENSMUSG00000038116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf20aENSDARG00000002750Danio rerio
 phf20bENSDARG00000038737Danio rerio
 PHF20ENSGALG00000001522Gallus gallus
 PHF20ENSG00000025293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CCJ9 / Phf20l1 / PHD finger protein 20-like protein 1 / A8MW92* / PHD finger protein 20 like 1*ENSMUSG0000007250132


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR004092  Mbt repeat
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR022255  Domain of unknown function DUF3776


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0071339 MLL1 complex ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Regulation of TP53 Degradation
Regulation of TP53 Activity through Association with Co-factors
Stabilization of p53


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex






 

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