ENSMUSG00000031732


Mus musculus

Features
Gene ID: ENSMUSG00000031732
  
Biological name :Phlpp2
  
Synonyms : PH domain leucine-rich repeat-containing protein phosphatase 2 / Phlpp2 / Q8BXA7
  
Possible biological names infered from orthology : PH domain and leucine rich repeat protein phosphatase 2 / Q6ZVD8
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 109868542
Gene end: 109944671
  
Corresponding Affymetrix probe sets: 10575328 (MoGene1.0st)   1435601_at (Mouse Genome 430 2.0 Array)   1444593_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034175
Ensembl peptide - ENSMUSP00000136166
NCBI entrez gene - 244650     See in Manteia.
MGI - MGI:2444928
RefSeq - NM_001122594
RefSeq - XM_006531010
RefSeq Peptide - NP_001116066
swissprot - J3QM82
swissprot - Q8BXA7
Ensembl - ENSMUSG00000031732
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phlpp2ENSDARG00000090255Danio rerio
 PHLPP2ENSGALG00000000875Gallus gallus
 PHLPP2ENSG00000040199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phlpp1 / Q8CHE4 / PH domain leucine-rich repeat-containing protein phosphatase 1 / O60346* / PH domain and leucine rich repeat protein phosphatase 1*ENSMUSG0000004434051


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001932  PPM-type phosphatase domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011993  PH-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0021766 hippocampus development IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of the PI3K/AKT network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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