ENSMUSG00000044340


Mus musculus

Features
Gene ID: ENSMUSG00000044340
  
Biological name :Phlpp1
  
Synonyms : PH domain leucine-rich repeat-containing protein phosphatase 1 / Phlpp1 / Q8CHE4
  
Possible biological names infered from orthology : O60346 / PH domain and leucine rich repeat protein phosphatase 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E2.1
Gene start: 106171752
Gene end: 106394250
  
Corresponding Affymetrix probe sets: 10349081 (MoGene1.0st)   1426994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056530
NCBI entrez gene - 98432     See in Manteia.
MGI - MGI:2138327
RefSeq - NM_133821
RefSeq Peptide - NP_598582
swissprot - Q8CHE4
Ensembl - ENSMUSG00000044340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phlpp1ENSDARG00000078694Danio rerio
 PHLPP1ENSGALG00000012888Gallus gallus
 O60346ENSG00000081913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phlpp2 / Q8BXA7 / PH domain leucine-rich repeat-containing protein phosphatase 2 / Q6ZVD8* / PH domain and leucine rich repeat protein phosphatase 2*ENSMUSG0000003173241


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001849  Pleckstrin homology domain
 IPR001932  PPM-type phosphatase domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011993  PH-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002667 regulation of T cell anergy IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0009649 entrainment of circadian clock IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IBA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0090036 regulation of protein kinase C signaling IBA
 biological_processGO:1900744 regulation of p38MAPK cascade IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of the PI3K/AKT network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
Genetic Background: involves: C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Ccnd1tm3Pisc/Ccnd1tm3Pisc
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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