ENSG00000081913


Homo sapiens

Features
Gene ID: ENSG00000081913
  
Biological name :PHLPP1
  
Synonyms : O60346 / PH domain and leucine rich repeat protein phosphatase 1 / PHLPP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.33
Gene start: 62715450
Gene end: 62980433
  
Corresponding Affymetrix probe sets: 210919_at (Human Genome U133 Plus 2.0 Array)   212719_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262719
Ensembl peptide - ENSP00000467279
NCBI entrez gene - 23239     See in Manteia.
OMIM - 609396
RefSeq - XM_011525886
RefSeq - NM_194449
RefSeq Peptide - NP_919431
swissprot - O60346
swissprot - K7EP91
Ensembl - ENSG00000081913
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phlpp1ENSDARG00000078694Danio rerio
 PHLPP1ENSGALG00000012888Gallus gallus
 Phlpp1ENSMUSG00000044340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHLPP2 / Q6ZVD8 / PH domain and leucine rich repeat protein phosphatase 2ENSG0000004019940


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001849  Pleckstrin homology domain
 IPR001932  PPM-type phosphatase domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011993  PH-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002667 regulation of T cell anergy IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009649 entrainment of circadian clock IEA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:0090036 regulation of protein kinase C signaling IBA
 biological_processGO:1900744 regulation of p38MAPK cascade IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of the PI3K/AKT network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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