ENSG00000040199


Homo sapiens

Features
Gene ID: ENSG00000040199
  
Biological name :PHLPP2
  
Synonyms : PH domain and leucine rich repeat protein phosphatase 2 / PHLPP2 / Q6ZVD8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.2
Gene start: 71637835
Gene end: 71724701
  
Corresponding Affymetrix probe sets: 213407_at (Human Genome U133 Plus 2.0 Array)   214944_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457991
Ensembl peptide - ENSP00000454519
Ensembl peptide - ENSP00000377159
Ensembl peptide - ENSP00000458660
Ensembl peptide - ENSP00000456572
NCBI entrez gene - 23035     See in Manteia.
OMIM - 611066
RefSeq - NM_001289003
RefSeq - NM_015020
RefSeq Peptide - NP_001275932
RefSeq Peptide - NP_055835
swissprot - Q6ZVD8
swissprot - H3BMS5
swissprot - H3BS75
swissprot - I3L187
Ensembl - ENSG00000040199
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phlpp2ENSDARG00000090255Danio rerio
 PHLPP2ENSGALG00000000875Gallus gallus
 Phlpp2ENSMUSG00000031732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60346 / PHLPP1 / PH domain and leucine rich repeat protein phosphatase 1ENSG0000008191352


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001932  PPM-type phosphatase domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011993  PH-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 cellular_componentGO:0001917 photoreceptor inner segment IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of the PI3K/AKT network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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