ENSMUSG00000029922


Mus musculus

Features
Gene ID: ENSMUSG00000029922
  
Biological name :Mkrn1
  
Synonyms : makorin, ring finger protein, 1 / Mkrn1 / Q9QXP6
  
Possible biological names infered from orthology : Q9UHC7
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 39397804
Gene end: 39420462
  
Corresponding Affymetrix probe sets: 10544186 (MoGene1.0st)   1418434_at (Mouse Genome 430 2.0 Array)   1418435_at (Mouse Genome 430 2.0 Array)   1434853_x_at (Mouse Genome 430 2.0 Array)   1441879_x_at (Mouse Genome 430 2.0 Array)   1451425_a_at (Mouse Genome 430 2.0 Array)   1455504_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121563
Ensembl peptide - ENSMUSP00000123440
Ensembl peptide - ENSMUSP00000031985
Ensembl peptide - ENSMUSP00000084244
Ensembl peptide - ENSMUSP00000110470
Ensembl peptide - ENSMUSP00000110471
Ensembl peptide - ENSMUSP00000115231
NCBI entrez gene - 54484     See in Manteia.
MGI - MGI:1859353
RefSeq - XM_017321683
RefSeq - NM_018810
RefSeq - XM_011241413
RefSeq - NM_001311109
RefSeq - XM_011241411
RefSeq - XM_011241412
RefSeq Peptide - NP_001298038
RefSeq Peptide - NP_061280
swissprot - Q8C5B6
swissprot - F6S742
swissprot - F6WPC3
swissprot - E9QAG7
swissprot - F6QJX8
swissprot - Q8C5V4
swissprot - Q99LD7
swissprot - Q9QXP6
Ensembl - ENSMUSG00000029922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mkrn1ENSDARG00000041665Danio rerio
 MKRN1ENSGALG00000012852Gallus gallus
 MKRN1ENSG00000133606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mkrn3 / Q60764 / Probable E3 ubiquitin-protein ligase makorin-3 / Q13064* / makorin ring finger protein 3*ENSMUSG0000007052745
Mkrn2 / Q9ERV1 / Probable E3 ubiquitin-protein ligase makorin-2 / Q9H000* / makorin ring finger protein 2*ENSMUSG0000000043938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR031644  E3 ubiquitin-protein ligase makorin 1, C-terminal
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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