ENSMUSG00000038909


Mus musculus

Features
Gene ID: ENSMUSG00000038909
  
Biological name :Kat7
  
Synonyms : Kat7 / K(lysine) acetyltransferase 7 / Q5SVQ0
  
Possible biological names infered from orthology : lysine acetyltransferase 7 / O95251
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 95274259
Gene end: 95310246
  
Corresponding Affymetrix probe sets: 10390153 (MoGene1.0st)   1433433_at (Mouse Genome 430 2.0 Array)   1447631_at (Mouse Genome 430 2.0 Array)   1459975_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121772
Ensembl peptide - ENSMUSP00000072416
Ensembl peptide - ENSMUSP00000090441
Ensembl peptide - ENSMUSP00000099448
Ensembl peptide - ENSMUSP00000103361
Ensembl peptide - ENSMUSP00000103362
NCBI entrez gene - 217127     See in Manteia.
MGI - MGI:2182799
RefSeq - XM_006533018
RefSeq - NM_001195003
RefSeq - NM_001195004
RefSeq - NM_177619
RefSeq - XM_006533013
RefSeq - XM_006533014
RefSeq - XM_006533015
RefSeq - XM_006533016
RefSeq Peptide - NP_001181932
RefSeq Peptide - NP_001181933
RefSeq Peptide - NP_808287
swissprot - Q3TD41
swissprot - Q1AJD0
swissprot - Q5SVQ0
swissprot - F6S4B9
Ensembl - ENSMUSG00000038909
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat7bENSDARG00000031770Danio rerio
 KAT7ENSGALG00000009944Gallus gallus
 KAT7ENSG00000136504Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kat6a / lysine acetyltransferase 6A / Q92794*ENSMUSG0000003154037
Kat6b / Q8BRB7 / Histone acetyltransferase KAT6B / Q8WYB5* / lysine acetyltransferase 6B*ENSMUSG0000002176736
Kat8 / Q9D1P2 / Histone acetyltransferase KAT8 / Q9H7Z6* / lysine acetyltransferase 8*ENSMUSG0000003080131
Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*ENSMUSG0000002492628


Protein motifs (from Interpro)
Interpro ID Name
 IPR002515  Zinc finger, C2HC-type
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade ISO
 biological_processGO:0043966 histone H3 acetylation ISS
 biological_processGO:0043981 histone H4-K5 acetylation ISO
 biological_processGO:0043982 histone H4-K8 acetylation ISO
 biological_processGO:0043983 histone H4-K12 acetylation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0072708 response to sorbitol ISO
 biological_processGO:0072710 response to hydroxyurea ISO
 biological_processGO:0072716 response to actinomycin D ISO
 biological_processGO:0072720 response to dithiothreitol ISO
 biological_processGO:0072739 response to anisomycin ISO
 biological_processGO:0090240 positive regulation of histone H4 acetylation ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 cellular_componentGO:0000123 histone acetyltransferase complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003688 DNA replication origin binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0010355 abnormal first branchial arch artery morphology "any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026283 Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*  / complex
 ENSMUSG00000025764 Jade1 / Q6ZPI0 / Protein Jade-1 / Q6IE81* / jade family PHD finger 1*  / complex
 ENSMUSG00000030330 Ing4 / Q8C0D7 / Inhibitor of growth protein 4 / Q9UNL4* / inhibitor of growth family member 4*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000028863 Meaf6 / Q2VPQ9 / MYST/Esa1-associated factor 6 / Q9HAF1*  / complex






 

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