ENSG00000136504


Homo sapiens

Features
Gene ID: ENSG00000136504
  
Biological name :KAT7
  
Synonyms : KAT7 / lysine acetyltransferase 7 / O95251
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 49788555
Gene end: 49835030
  
Corresponding Affymetrix probe sets: 200049_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421368
Ensembl peptide - ENSP00000413415
Ensembl peptide - ENSP00000423385
Ensembl peptide - ENSP00000424577
Ensembl peptide - ENSP00000259021
Ensembl peptide - ENSP00000398961
Ensembl peptide - ENSP00000409477
NCBI entrez gene - 11143     See in Manteia.
OMIM - 609880
RefSeq - XM_011524235
RefSeq - NM_001199155
RefSeq - NM_001199156
RefSeq - NM_001199157
RefSeq - NM_001199158
RefSeq - NM_007067
RefSeq Peptide - NP_001186087
RefSeq Peptide - NP_008998
RefSeq Peptide - NP_001186085
RefSeq Peptide - NP_001186084
RefSeq Peptide - NP_001186086
swissprot - O95251
swissprot - E7EUP3
swissprot - D6RFZ5
Ensembl - ENSG00000136504
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat7bENSDARG00000031770Danio rerio
 KAT7ENSGALG00000009944Gallus gallus
 Kat7ENSMUSG00000038909Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KAT6B / Q8WYB5 / lysine acetyltransferase 6BENSG0000015665037
KAT6A / Q92794 / lysine acetyltransferase 6AENSG0000008316836
KAT8 / Q9H7Z6 / lysine acetyltransferase 8ENSG0000010351030
KAT5 / Q92993 / lysine acetyltransferase 5ENSG0000017297729


Protein motifs (from Interpro)
Interpro ID Name
 IPR002515  Zinc finger, C2HC-type
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR036060  Zinc finger, C2HC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IDA
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043983 histone H4-K12 acetylation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0072708 response to sorbitol IMP
 biological_processGO:0072710 response to hydroxyurea IMP
 biological_processGO:0072716 response to actinomycin D IMP
 biological_processGO:0072720 response to dithiothreitol IMP
 biological_processGO:0072739 response to anisomycin IMP
 biological_processGO:0090240 positive regulation of histone H4 acetylation IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus IDA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003688 DNA replication origin binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077684 JADE1 / Q6IE81 / jade family PHD finger 1  / complex
 ENSG00000163875 MEAF6 / Q9HAF1 / MYST/Esa1 associated factor 6  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000111653 ING4 / Q9UNL4 / inhibitor of growth family member 4  / complex
 ENSG00000168395 ING5 / Q8WYH8 / inhibitor of growth family member 5  / complex






 

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