ENSG00000077684


Homo sapiens

Features
Gene ID: ENSG00000077684
  
Biological name :JADE1
  
Synonyms : JADE1 / jade family PHD finger 1 / Q6IE81
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q28.2
Gene start: 128809623
Gene end: 128875224
  
Corresponding Affymetrix probe sets: 218517_at (Human Genome U133 Plus 2.0 Array)   225816_at (Human Genome U133 Plus 2.0 Array)   225820_at (Human Genome U133 Plus 2.0 Array)   235024_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422445
Ensembl peptide - ENSP00000423737
Ensembl peptide - ENSP00000483219
Ensembl peptide - ENSP00000482212
Ensembl peptide - ENSP00000426920
Ensembl peptide - ENSP00000426590
Ensembl peptide - ENSP00000425730
Ensembl peptide - ENSP00000425535
Ensembl peptide - ENSP00000424280
Ensembl peptide - ENSP00000226319
Ensembl peptide - ENSP00000388015
Ensembl peptide - ENSP00000404211
Ensembl peptide - ENSP00000421265
Ensembl peptide - ENSP00000421778
NCBI entrez gene - 79960     See in Manteia.
OMIM - 610514
RefSeq - XM_017008627
RefSeq - NM_001287437
RefSeq - NM_001287439
RefSeq - NM_001287440
RefSeq - NM_001287441
RefSeq - NM_001287442
RefSeq - NM_001287443
RefSeq - NM_024900
RefSeq - NM_199320
RefSeq - XM_005263232
RefSeq - XM_017008626
RefSeq Peptide - NP_079176
RefSeq Peptide - NP_955352
RefSeq Peptide - NP_001274366
RefSeq Peptide - NP_001274368
RefSeq Peptide - NP_001274369
RefSeq Peptide - NP_001274370
RefSeq Peptide - NP_001274371
RefSeq Peptide - NP_001274372
swissprot - D6RCS1
swissprot - D6RC05
swissprot - Q6IE81
swissprot - D6RGE7
swissprot - D6RBB3
swissprot - D6RAS5
swissprot - D6RFK0
swissprot - D6RE74
Ensembl - ENSG00000077684
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jade1ENSDARG00000033707Danio rerio
 JADE1ENSGALG00000010214Gallus gallus
 Jade1ENSMUSG00000025764Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JADE2 / Q9NQC1 / jade family PHD finger 2ENSG0000004314349
JADE3 / Q92613 / jade family PHD finger 3ENSG0000010222144
BRPF3 / Q9ULD4 / bromodomain and PHD finger containing 3ENSG0000009607022
BRD1 / O95696 / bromodomain containing 1ENSG0000010042521
BRPF1 / P55201 / bromodomain and PHD finger containing 1ENSG0000015698320
MLLT6 / MLLT6, PHD finger containingENSG0000027502317
MLLT10 / P55197 / MLLT10, histone lysine methyltransferase DOT1L cofactorENSG0000007840317
PHF14 / O94880 / PHD finger protein 14ENSG0000010644315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019542  Enhancer of polycomb-like, N-terminal
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043983 histone H4-K12 acetylation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000136504 KAT7 / O95251 / lysine acetyltransferase 7  / complex
 ENSG00000163875 MEAF6 / Q9HAF1 / MYST/Esa1 associated factor 6  / complex
 ENSG00000168395 ING5 / Q8WYH8 / inhibitor of growth family member 5  / complex
 ENSG00000111653 ING4 / Q9UNL4 / inhibitor of growth family member 4  / complex






 

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