ENSG00000168395


Homo sapiens

Features
Gene ID: ENSG00000168395
  
Biological name :ING5
  
Synonyms : ING5 / inhibitor of growth family member 5 / Q8WYH8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 241687085
Gene end: 241729478
  
Corresponding Affymetrix probe sets: 223871_x_at (Human Genome U133 Plus 2.0 Array)   228287_at (Human Genome U133 Plus 2.0 Array)   229197_at (Human Genome U133 Plus 2.0 Array)   241447_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416878
Ensembl peptide - ENSP00000490767
Ensembl peptide - ENSP00000322142
Ensembl peptide - ENSP00000385937
NCBI entrez gene - 84289     See in Manteia.
OMIM - 608525
RefSeq - XM_017005102
RefSeq - XM_005247047
RefSeq - XM_017005097
RefSeq - XM_017005098
RefSeq - XM_017005099
RefSeq - XM_017005100
RefSeq - XM_017005101
RefSeq - NM_001330161
RefSeq - NM_001330162
RefSeq - NM_032329
RefSeq Peptide - NP_115705
RefSeq Peptide - NP_001317090
RefSeq Peptide - NP_001317091
swissprot - E9PEN0
swissprot - Q8WYH8
swissprot - A0A1B0GW41
Ensembl - ENSG00000168395
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing5aENSDARG00000022413Danio rerio
 ing5bENSDARG00000068175Danio rerio
 ING5ENSGALG00000006317Gallus gallus
 Ing5ENSMUSG00000026283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ING4 / Q9UNL4 / inhibitor of growth family member 4ENSG0000011165346
ING3 / Q9NXR8 / inhibitor of growth family member 3ENSG0000007124321
ING2 / Q9H160 / inhibitor of growth family member 2ENSG0000016855620
ING1 / Q9UK53 / inhibitor of growth family member 1ENSG0000015348717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028638  Inhibitor of growth protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045926 negative regulation of growth IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0070776 MOZ/MORF histone acetyltransferase complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Regulation of TP53 Activity through Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136504 KAT7 / O95251 / lysine acetyltransferase 7  / complex
 ENSG00000083168 KAT6A / Q92794 / lysine acetyltransferase 6A  / complex
 ENSG00000163875 MEAF6 / Q9HAF1 / MYST/Esa1 associated factor 6  / complex
 ENSG00000168395 ING5 / Q8WYH8 / inhibitor of growth family member 5  / complex
 ENSG00000156650 KAT6B / Q8WYB5 / lysine acetyltransferase 6B  / complex
 ENSG00000140464 PML / P29590 / promyelocytic leukemia  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000077684 JADE1 / Q6IE81 / jade family PHD finger 1  / complex
 ENSG00000156983 BRPF1 / P55201 / bromodomain and PHD finger containing 1  / complex
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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