ENSG00000168556


Homo sapiens

Features
Gene ID: ENSG00000168556
  
Biological name :ING2
  
Synonyms : ING2 / inhibitor of growth family member 2 / Q9H160
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q35.1
Gene start: 183504994
Gene end: 183511096
  
Corresponding Affymetrix probe sets: 205981_s_at (Human Genome U133 Plus 2.0 Array)   213544_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410291
Ensembl peptide - ENSP00000307183
NCBI entrez gene - 3622     See in Manteia.
OMIM - 604215
RefSeq - NM_001291959
RefSeq - NM_001564
RefSeq Peptide - NP_001278888
RefSeq Peptide - NP_001555
swissprot - Q9H160
swissprot - C9J4X5
Ensembl - ENSG00000168556
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing2ENSDARG00000104907Danio rerio
 ING2ENSGALG00000010659Gallus gallus
 Ing2ENSMUSG00000063049Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ING1 / Q9UK53 / inhibitor of growth family member 1ENSG0000015348751
ING4 / Q9UNL4 / inhibitor of growth family member 4ENSG0000011165331
ING3 / Q9NXR8 / inhibitor of growth family member 3ENSG0000007124329
ING5 / Q8WYH8 / inhibitor of growth family member 5ENSG0000016839519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028639  Inhibitor of growth protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007141 male meiosis I ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048133 male germ-line stem cell asymmetric division ISS
 biological_processGO:0072520 seminiferous tubule development ISS
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
 biological_processGO:2000772 regulation of cellular senescence IEA
 biological_processGO:2001020 regulation of response to DNA damage stimulus NAS
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0016580 Sin3 complex IDA
 cellular_componentGO:0016602 CCAAT-binding factor complex IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
PI5P Regulates TP53 Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction






 

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