ENSMUSG00000063049


Mus musculus

Features
Gene ID: ENSMUSG00000063049
  
Biological name :Ing2
  
Synonyms : Ing2 / Inhibitor of growth protein 2 / Q9ESK4
  
Possible biological names infered from orthology : inhibitor of growth family member 2 / Q9H160
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B1.1
Gene start: 47667178
Gene end: 47675556
  
Corresponding Affymetrix probe sets: 10578615 (MoGene1.0st)   1419111_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079226
NCBI entrez gene - 69260     See in Manteia.
MGI - MGI:1916510
RefSeq - NM_023503
RefSeq Peptide - NP_075992
swissprot - Q9ESK4
Ensembl - ENSMUSG00000063049
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing2ENSDARG00000104907Danio rerio
 ING2ENSGALG00000010659Gallus gallus
 ING2ENSG00000168556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ing1 / Q9QXV3 / Inhibitor of growth protein 1 / Q9UK53* / inhibitor of growth family member 1*ENSMUSG0000004596959
Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*ENSMUSG0000002628332
Ing4 / Q8C0D7 / Inhibitor of growth protein 4 / Q9UNL4* / inhibitor of growth family member 4*ENSMUSG0000003033031
Ing3 / Q8VEK6 / Inhibitor of growth protein 3 / Q9NXR8* / inhibitor of growth family member 3*ENSMUSG0000002967027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028639  Inhibitor of growth protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048133 male germ-line stem cell asymmetric division IMP
 biological_processGO:0072520 seminiferous tubule development IMP
 biological_processGO:2000772 regulation of cellular senescence IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0016602 CCAAT-binding factor complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
PI5P Regulates TP53 Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Ing2tm1.1Ccha/Ing2tm1.1Ccha,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Ing2tm1.1Ccha/Ing2tm1.1Ccha,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Ing2tm1.1Ccha/Ing2tm1.1Ccha,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Ing2tm1.1Ccha/Ing2tm1.1Ccha,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Allelic Composition: Ing2tm1.1Ccha/Ing2tm1.1Ccha,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009233 enlarged sperm head "increased size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009839 multiflagellated sperm "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0013538 increased Harderian gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the Harderian gland, occurring in a specific population in a given time period " [MGI:Anna]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

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