ENSMUSG00000045969


Mus musculus

Features
Gene ID: ENSMUSG00000045969
  
Biological name :Ing1
  
Synonyms : Ing1 / Inhibitor of growth protein 1 / Q9QXV3
  
Possible biological names infered from orthology : inhibitor of growth family member 1 / Q9UK53
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 11555571
Gene end: 11563251
  
Corresponding Affymetrix probe sets: 10570131 (MoGene1.0st)   1416860_s_at (Mouse Genome 430 2.0 Array)   1433267_at (Mouse Genome 430 2.0 Array)   1448496_a_at (Mouse Genome 430 2.0 Array)   1454534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148030
Ensembl peptide - ENSMUSP00000148023
Ensembl peptide - ENSMUSP00000148248
Ensembl peptide - ENSMUSP00000062593
Ensembl peptide - ENSMUSP00000147270
Ensembl peptide - ENSMUSP00000147476
Ensembl peptide - ENSMUSP00000147892
NCBI entrez gene - 26356     See in Manteia.
MGI - MGI:1349481
RefSeq - NM_001302457
RefSeq - NM_001302451
RefSeq - NM_001302458
RefSeq - NM_001302459
RefSeq - NM_001302460
RefSeq - NM_011919
RefSeq Peptide - NP_001289388
RefSeq Peptide - NP_001289386
RefSeq Peptide - NP_001289389
RefSeq Peptide - NP_036049
RefSeq Peptide - NP_001289387
RefSeq Peptide - NP_001289380
swissprot - A0A1B0GT89
swissprot - Q9QXV3
swissprot - Q3ULE3
swissprot - A0A1B0GSP9
Ensembl - ENSMUSG00000045969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing1ENSDARG00000019116Danio rerio
 ING1ENSGALG00000016849Gallus gallus
 ING1ENSG00000153487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ing2 / Q9ESK4 / Inhibitor of growth protein 2 / Q9H160* / inhibitor of growth family member 2*ENSMUSG0000006304959
Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*ENSMUSG0000002628335
Ing4 / Q8C0D7 / Inhibitor of growth protein 4 / Q9UNL4* / inhibitor of growth family member 4*ENSMUSG0000003033035
Ing3 / Q8VEK6 / Inhibitor of growth protein 3 / Q9NXR8* / inhibitor of growth family member 3*ENSMUSG0000002967032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028643  Inhibitor of growth protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010941 regulation of cell death IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IMP
 molecular_functionGO:0035064 methylated histone binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ing1Gt(F066C08)Irpa/Ing1Gt(F066C08)Irpa
Genetic Background: involves: 129S2/SvPas

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1Gt(OST206270)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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