Manteia

ENSMUSG00000030330

Mus musculus

Features

Gene ID:	ENSMUSG00000030330

Biological name :	Ing4

Synonyms :	Ing4 / Inhibitor of growth protein 4 / Q8C0D7

Possible biological names infered from orthology :	inhibitor of growth family member 4 / Q9UNL4

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	F2
Gene start:	125039760
Gene end:	125049265

Corresponding Affymetrix probe sets:	10541771 (MoGene1.0st) 1448054_at (Mouse Genome 430 2.0 Array) 1460728_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000032480 Ensembl peptide - ENSMUSP00000108036 Ensembl peptide - ENSMUSP00000121519 NCBI entrez gene - 28019 See in Manteia. MGI - MGI:107307 RefSeq - NM_133345 RefSeq Peptide - NP_579923 swissprot - Q8C0D7 Ensembl - ENSMUSG00000030330

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ing4	ENSDARG00000030716	Danio rerio
ING4	ENSGALG00000014457	Gallus gallus
ING4	ENSG00000111653	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*	ENSMUSG00000026283	69
Ing1 / Q9QXV3 / Inhibitor of growth protein 1 / Q9UK53* / inhibitor of growth family member 1*	ENSMUSG00000045969	40
Ing3 / Q8VEK6 / Inhibitor of growth protein 3 / Q9NXR8* / inhibitor of growth family member 3*	ENSMUSG00000029670	36
Ing2 / Q9ESK4 / Inhibitor of growth protein 2 / Q9H160* / inhibitor of growth family member 2*	ENSMUSG00000063049	35

Protein motifs (from Interpro)

Interpro ID	Name
IPR001965	Zinc finger, PHD-type
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR019786	Zinc finger, PHD-type, conserved site
IPR019787	Zinc finger, PHD-finger
IPR024610	Inhibitor of growth protein, N-terminal histone-binding
IPR028647	Inhibitor of growth protein 4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006260	DNA replication	ISO
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006473	protein acetylation	ISO
biological_process	GO:0006915	apoptotic process	ISO
biological_process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISS
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007050	cell cycle arrest	ISO
biological_process	GO:0008285	negative regulation of cell proliferation	ISO
biological_process	GO:0016573	histone acetylation	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	ISS
biological_process	GO:0043966	histone H3 acetylation	ISS
biological_process	GO:0043981	histone H4-K5 acetylation	ISO
biological_process	GO:0043982	histone H4-K8 acetylation	ISO
biological_process	GO:0043983	histone H4-K12 acetylation	ISO
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045926	negative regulation of growth	ISO
cellular_component	GO:0000123	histone acetyltransferase complex	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0045111	intermediate filament cytoskeleton	ISO
molecular_function	GO:0003713	transcription coactivator activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0035064	methylated histone binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

HATs acetylate histones

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Med31^l11Jus15/Med31^l11Jus15 Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Med31^l11Jus15/Med31^l11Jus15 Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008721	abnormal chemokine level	"deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Med31^l11Jus15/Med31^l11Jus15 Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Med31^l11Jus15/Med31^l11Jus15 Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028863	Meaf6 / Q2VPQ9 / MYST/Esa1-associated factor 6 / Q9HAF1*	/ complex
ENSMUSG00000025764	Jade1 / Q6ZPI0 / Protein Jade-1 / Q6IE81* / jade family PHD finger 1*	/ complex
ENSMUSG00000038909	Kat7 / Q5SVQ0 / K(lysine) acetyltransferase 7 / O95251* / lysine acetyltransferase 7*	/ complex
ENSMUSG00000099517	P68433 / Hist1h3g / Histone H3.1	/ reaction
ENSMUSG00000030330	Ing4 / Q8C0D7 / Inhibitor of growth protein 4 / Q9UNL4* / inhibitor of growth family member 4*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr