ENSG00000111653


Homo sapiens

Features
Gene ID: ENSG00000111653
  
Biological name :ING4
  
Synonyms : ING4 / inhibitor of growth family member 4 / Q9UNL4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 6650280
Gene end: 6663148
  
Corresponding Affymetrix probe sets: 218234_at (Human Genome U133 Plus 2.0 Array)   48825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436406
Ensembl peptide - ENSP00000435867
Ensembl peptide - ENSP00000437198
Ensembl peptide - ENSP00000480978
Ensembl peptide - ENSP00000473635
Ensembl peptide - ENSP00000343396
Ensembl peptide - ENSP00000380024
Ensembl peptide - ENSP00000397343
Ensembl peptide - ENSP00000412705
Ensembl peptide - ENSP00000414008
Ensembl peptide - ENSP00000415903
Ensembl peptide - ENSP00000431892
Ensembl peptide - ENSP00000433081
NCBI entrez gene - 51147     See in Manteia.
OMIM - 608524
RefSeq - XM_017019393
RefSeq - NM_001127582
RefSeq - NM_001127583
RefSeq - NM_001127584
RefSeq - NM_001127585
RefSeq - NM_001127586
RefSeq - NM_016162
RefSeq - XM_005253698
RefSeq - XM_011520964
RefSeq - XM_011520965
RefSeq - XM_017019392
RefSeq Peptide - NP_001121054
RefSeq Peptide - NP_001121056
RefSeq Peptide - NP_001121057
RefSeq Peptide - NP_001121058
RefSeq Peptide - NP_057246
RefSeq Peptide - NP_001121055
swissprot - R4GNG1
swissprot - A4KYM5
swissprot - E9PNE3
swissprot - E9PJ14
swissprot - H0YEH7
swissprot - Q9UNL4
Ensembl - ENSG00000111653
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing4ENSDARG00000030716Danio rerio
 ING4ENSGALG00000014457Gallus gallus
 Ing4ENSMUSG00000030330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ING5 / Q8WYH8 / inhibitor of growth family member 5ENSG0000016839547
ING2 / Q9H160 / inhibitor of growth family member 2ENSG0000016855635
ING3 / Q9NXR8 / inhibitor of growth family member 3ENSG0000007124335
ING1 / Q9UK53 / inhibitor of growth family member 1ENSG0000015348733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028647  Inhibitor of growth protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043983 histone H4-K12 acetylation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045926 negative regulation of growth IDA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136504 KAT7 / O95251 / lysine acetyltransferase 7  / complex
 ENSG00000163875 MEAF6 / Q9HAF1 / MYST/Esa1 associated factor 6  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000111653 ING4 / Q9UNL4 / inhibitor of growth family member 4  / complex
 ENSG00000077684 JADE1 / Q6IE81 / jade family PHD finger 1  / complex






 

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