ENSG00000153487


Homo sapiens

Features
Gene ID: ENSG00000153487
  
Biological name :ING1
  
Synonyms : ING1 / inhibitor of growth family member 1 / Q9UK53
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 110712736
Gene end: 110723339
  
Corresponding Affymetrix probe sets: 208415_x_at (Human Genome U133 Plus 2.0 Array)   209808_x_at (Human Genome U133 Plus 2.0 Array)   210350_x_at (Human Genome U133 Plus 2.0 Array)   244177_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480985
Ensembl peptide - ENSP00000345202
Ensembl peptide - ENSP00000364929
Ensembl peptide - ENSP00000364930
Ensembl peptide - ENSP00000328436
NCBI entrez gene - 3621     See in Manteia.
OMIM - 601566
RefSeq - NM_005537
RefSeq - NM_001267728
RefSeq - NM_198217
RefSeq - NM_198218
RefSeq - NM_198219
RefSeq Peptide - NP_937862
RefSeq Peptide - NP_005528
RefSeq Peptide - NP_937860
RefSeq Peptide - NP_937861
RefSeq Peptide - NP_001254657
swissprot - Q9UK53
swissprot - A0A0C4DFW2
swissprot - A0A087WXF7
Ensembl - ENSG00000153487
  
Related genetic diseases (OMIM): 275355 - Squamous cell carcinoma, head and neck, somatic, 275355
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing1ENSDARG00000019116Danio rerio
 ING1ENSGALG00000016849Gallus gallus
 Ing1ENSMUSG00000045969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ING2 / Q9H160 / inhibitor of growth family member 2ENSG0000016855634
ING4 / Q9UNL4 / inhibitor of growth family member 4ENSG0000011165320
ING3 / Q9NXR8 / inhibitor of growth family member 3ENSG0000007124318
ING5 / Q8WYH8 / inhibitor of growth family member 5ENSG0000016839510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028643  Inhibitor of growth protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010941 regulation of cell death IEA
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0002860 Squamous cell carcinoma 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr