ENSG00000103510


Homo sapiens

Features
Gene ID: ENSG00000103510
  
Biological name :KAT8
  
Synonyms : KAT8 / lysine acetyltransferase 8 / Q9H7Z6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 31115754
Gene end: 31131393
  
Corresponding Affymetrix probe sets: 214885_at (Human Genome U133 Plus 2.0 Array)   221820_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000219797
Ensembl peptide - ENSP00000406037
Ensembl peptide - ENSP00000454592
Ensembl peptide - ENSP00000456933
NCBI entrez gene - 84148     See in Manteia.
OMIM - 609912
RefSeq - XM_011545971
RefSeq - NM_032188
RefSeq - NM_182958
RefSeq - XM_011545970
RefSeq Peptide - NP_892003
RefSeq Peptide - NP_115564
swissprot - Q9H7Z6
swissprot - H3BMX5
Ensembl - ENSG00000103510
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat8ENSDARG00000027187Danio rerio
 Kat8ENSMUSG00000030801Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KAT7 / O95251 / lysine acetyltransferase 7ENSG0000013650439
KAT6A / Q92794 / lysine acetyltransferase 6AENSG0000008316836
KAT5 / Q92993 / lysine acetyltransferase 5ENSG0000017297736
KAT6B / Q8WYB5 / lysine acetyltransferase 6BENSG0000015665036


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR025995  RNA binding activity-knot of a chromodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010506 regulation of autophagy IDA
 biological_processGO:0016573 histone acetylation IDA
 biological_processGO:0030099 myeloid cell differentiation IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043984 histone H4-K16 acetylation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0071339 MLL1 complex IDA
 cellular_componentGO:0072487 MSL complex IDA
 molecular_functionGO:0004402 histone acetyltransferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0016407 acetyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IDA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IDA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005302 MSL3 / Q8N5Y2 / MSL complex subunit 3  / complex
 ENSG00000174579 MSL2 / Q9HCI7 / MSL complex subunit 2  / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000188895 MSL1 / Q68DK7 / male specific lethal 1 homolog  / complex






 

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