ENSMUSG00000032405


Mus musculus

Features
Gene ID: ENSMUSG00000032405
  
Biological name :Pias1
  
Synonyms : O88907 / Pias1 / protein inhibitor of activated STAT 1
  
Possible biological names infered from orthology : O75925
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 62878368
Gene end: 62987924
  
Corresponding Affymetrix probe sets: 10594322 (MoGene1.0st)   1422581_at (Mouse Genome 430 2.0 Array)   1446448_at (Mouse Genome 430 2.0 Array)   1455486_at (Mouse Genome 430 2.0 Array)   1455611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149590
Ensembl peptide - ENSMUSP00000150834
Ensembl peptide - ENSMUSP00000096248
Ensembl peptide - ENSMUSP00000149235
NCBI entrez gene - 56469     See in Manteia.
MGI - MGI:1913125
RefSeq - NM_019663
RefSeq - XM_006511302
RefSeq Peptide - NP_062637
swissprot - Q2M4G9
swissprot - Q3U556
swissprot - O88907
swissprot - A0A1L1SQX9
swissprot - A0A1L1SRS2
Ensembl - ENSMUSG00000032405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pias1aENSDARG00000036094Danio rerio
 pias1bENSDARG00000062445Danio rerio
 PIAS1ENSGALG00000007970Gallus gallus
 PIAS1ENSG00000033800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pias3 / O54714 / E3 SUMO-protein ligase PIAS3 / Q9Y6X2* / protein inhibitor of activated STAT 3*ENSMUSG0000002810158
Pias2 / Q8C5D8 / E3 SUMO-protein ligase PIAS2 / O75928* / protein inhibitor of activated STAT 2*ENSMUSG0000002542356
Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*ENSMUSG0000000493437
Zmiz1 / Q6P1E1 / zinc finger, MIZ-type containing 1 / Q9ULJ6*ENSMUSG0000000781722
Zmiz2 / Q8CIE2 / zinc finger, MIZ-type containing 2 / Q8NF64*ENSMUSG0000004116421


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007259 JAK-STAT cascade ISO
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0016925 protein sumoylation ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0065004 protein-DNA complex assembly IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061665 SUMO ligase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

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