ENSGALG00000005006


Gallus gallus

Features
Gene ID: ENSGALG00000005006
  
Biological name :UBA2
  
Synonyms : SUMO-activating enzyme subunit 2 / UBA2
  
Possible biological names infered from orthology : Q9UBT2 / Q9Z1F9 / ubiquitin like modifier activating enzyme 2
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 11258200
Gene end: 11281700
  
Corresponding Affymetrix probe sets: Gga.5383.2.S1_at (Chicken Array)   GgaAffx.12210.1.S1_at (Chicken Array)   GgaAffx.12210.1.S1_s_at (Chicken Array)   GgaAffx.12955.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055468
Ensembl peptide - ENSGALP00000008003
Ensembl peptide - ENSGALP00000028895
NCBI entrez gene - 415785     See in Manteia.
NCBI entrez gene - 415784     See in Manteia.
RefSeq - XM_015292448
RefSeq - NM_001030571
RefSeq - NM_001030572
RefSeq - XM_015292444
RefSeq - XM_015292445
RefSeq - XM_015292447
RefSeq Peptide - NP_001025743
RefSeq Peptide - NP_001025742
swissprot - F1NB23
swissprot - F1P226
swissprot - A0A1D5PRE4
Ensembl - ENSGALG00000005006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba2ENSDARG00000101332Danio rerio
 UBA2ENSG00000126261Homo sapiens
 Uba2ENSMUSG00000052997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR007320  Programmed cell death protein 2, C-terminal
 IPR016040  NAD(P)-binding domain
 IPR018074  Ubiquitin-activating enzyme E1, conserved site
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR028077  Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
 IPR030661  SUMO-activating enzyme subunit Uba2
 IPR032426  SUMO-activating enzyme subunit 2, C-terminal domain
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031510 SUMO activating enzyme complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016881 acid-amino acid ligase activity IEA
 molecular_functionGO:0019948 SUMO activating enzyme activity IBA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IEA
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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