ENSG00000126261


Homo sapiens

Features
Gene ID: ENSG00000126261
  
Biological name :UBA2
  
Synonyms : Q9UBT2 / UBA2 / ubiquitin like modifier activating enzyme 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.11
Gene start: 34428352
Gene end: 34471251
  
Corresponding Affymetrix probe sets: 201177_s_at (Human Genome U133 Plus 2.0 Array)   229587_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475656
Ensembl peptide - ENSP00000468756
Ensembl peptide - ENSP00000475565
Ensembl peptide - ENSP00000246548
Ensembl peptide - ENSP00000437484
Ensembl peptide - ENSP00000467433
Ensembl peptide - ENSP00000468538
NCBI entrez gene - 10054     See in Manteia.
OMIM - 613295
RefSeq - XM_017026134
RefSeq - NM_005499
RefSeq - XM_005258404
RefSeq - XM_006722962
RefSeq - XM_011526304
RefSeq Peptide - NP_005490
swissprot - U3KQ55
swissprot - U3KQ93
swissprot - Q9UBT2
swissprot - K7ESK7
swissprot - K7EPL2
swissprot - K7ES38
Ensembl - ENSG00000126261
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba2ENSDARG00000101332Danio rerio
 UBA2ENSGALG00000005006Gallus gallus
 Uba2ENSMUSG00000052997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018074  Ubiquitin-activating enzyme E1, conserved site
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR023318  Ubiquitin activating enzyme, alpha domain superfamily
 IPR028077  Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
 IPR030661  SUMO-activating enzyme subunit Uba2
 IPR032426  SUMO-activating enzyme subunit 2, C-terminal domain
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031510 SUMO activating enzyme complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016881 acid-amino acid ligase activity IEA
 molecular_functionGO:0019948 SUMO activating enzyme activity IEA
 molecular_functionGO:0032183 SUMO binding IPI
 molecular_functionGO:0044388 small protein activating enzyme binding IPI
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IMP


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000142230 SAE1 / Q9UBE0 / SUMO1 activating enzyme subunit 1  / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

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