ENSG00000142230


Homo sapiens

Features
Gene ID: ENSG00000142230
  
Biological name :SAE1
  
Synonyms : Q9UBE0 / SAE1 / SUMO1 activating enzyme subunit 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 47113274
Gene end: 47210636
  
Corresponding Affymetrix probe sets: 1555618_s_at (Human Genome U133 Plus 2.0 Array)   217946_s_at (Human Genome U133 Plus 2.0 Array)   241185_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471010
Ensembl peptide - ENSP00000470741
Ensembl peptide - ENSP00000472389
Ensembl peptide - ENSP00000473037
Ensembl peptide - ENSP00000270225
Ensembl peptide - ENSP00000398818
Ensembl peptide - ENSP00000416557
Ensembl peptide - ENSP00000440818
Ensembl peptide - ENSP00000468931
Ensembl peptide - ENSP00000469938
Ensembl peptide - ENSP00000469978
NCBI entrez gene - 10055     See in Manteia.
OMIM - 613294
RefSeq - XM_017026136
RefSeq - NM_001145713
RefSeq - NM_001145714
RefSeq - NM_005500
RefSeq - XM_006722963
RefSeq - XM_006722965
RefSeq - XM_017026135
RefSeq Peptide - NP_005491
RefSeq Peptide - NP_001139185
RefSeq Peptide - NP_001139186
swissprot - A0A024R0R4
swissprot - B3KNJ4
swissprot - M0QX65
swissprot - M0QYM8
swissprot - M0QYP2
swissprot - M0QZS6
swissprot - M0R286
swissprot - M0R054
swissprot - M0R375
swissprot - Q9UBE0
Ensembl - ENSG00000142230
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sae1ENSDARG00000010487Danio rerio
 Sae1ENSMUSG00000052833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031510 SUMO activating enzyme complex IDA
 molecular_functionGO:0004839 ubiquitin activating enzyme activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IDA
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019948 SUMO activating enzyme activity IDA
 molecular_functionGO:0043008 ATP-dependent protein binding IDA
 molecular_functionGO:0044388 small protein activating enzyme binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / complex / reaction
 ENSG00000126261 UBA2 / Q9UBT2 / ubiquitin like modifier activating enzyme 2  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr