ENSGALG00000039583


Gallus gallus

Features
Gene ID: ENSGALG00000039583
  
Biological name :MITF
  
Synonyms : microphthalmia-associated transcription factor / MITF
  
Possible biological names infered from orthology : melanogenesis associated transcription factor / O75030 / Q08874
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 15509714
Gene end: 15595891
  
Corresponding Affymetrix probe sets: Gga.275.1.S1_at (Chicken Array)   Gga.275.2.S1_a_at (Chicken Array)   Gga.275.3.S1_a_at (Chicken Array)   Gga.7499.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045630
Ensembl peptide - ENSGALP00000044345
NCBI entrez gene - 395886     See in Manteia.
RefSeq - XM_015292974
RefSeq - NM_205029
RefSeq - XM_015292971
RefSeq - XM_015292972
RefSeq - XM_015292973
RefSeq - XM_015292966
RefSeq - XM_015292967
RefSeq - XM_015292968
RefSeq - XM_015292969
RefSeq - XM_015292970
RefSeq Peptide - NP_990360
swissprot - Q9IAU0
swissprot - A0A1D5NVH0
Ensembl - ENSGALG00000039583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mitfaENSDARG00000003732Danio rerio
 mitfbENSDARG00000037833Danio rerio
 MITFENSG00000187098Homo sapiens
 MitfENSMUSG00000035158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TFEB / transcription factor EB / P19484* / Q9R210*ENSGALG0000003987842
TFEC / transcription factor EC / O14948* / Q9WTW4*ENSGALG0000004055738


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR021802  MiT/TFE transcription factors, C-terminal
 IPR030532  Microphthalmia-associated transcription factor
 IPR031867  MiT/TFE transcription factors, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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