ENSDARG00000003732


Danio rerio

Features
Gene ID: ENSDARG00000003732
  
Biological name :mitfa
  
Synonyms : microphthalmia-associated transcription factor a / mitfa
  
Possible biological names infered from orthology : melanogenesis associated transcription factor / MITF / O75030 / Q08874
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 43390387
Gene end: 43433277
  
Corresponding Affymetrix probe sets: Dr.8080.1.S1_at (Zebrafish Array)   NM_130923_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000106194
Ensembl peptide - ENSDARP00000056456
Ensembl peptide - ENSDARP00000114096
NCBI entrez gene - 30080     See in Manteia.
RefSeq - NM_130923
RefSeq - XM_021476774
RefSeq Peptide - NP_570998
swissprot - F1QMU5
swissprot - E9QC93
swissprot - Q9PWC2
ZFIN ID - ZDB-GENE-990910-11
Ensembl - ENSDARG00000003732
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MITFENSGALG00000039583Gallus gallus
 MITFENSG00000187098Homo sapiens
 MitfENSMUSG00000035158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mitfb / microphthalmia-associated transcription factor b / MITF* / O75030* / melanogenesis associated transcription factor*ENSDARG0000003783368
tfe3a / transcription factor binding to IGHM enhancer 3a / TFE3* / Q64092* / P19532* / Transcription factor E3 * / transcription factor binding to IGHM enhancer 3*ENSDARG0000009890348
tfe3b / transcription factor binding to IGHM enhancer 3b / TFE3* / Q64092* / P19532* / Transcription factor E3 * / transcription factor binding to IGHM enhancer 3*ENSDARG0000001945747
tfeb / transcription factor EB / P19484* / Q9R210*ENSDARG0000001079445
tfec / transcription factor EC / O14948*ENSDARG0000009874541


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR021802  MiT/TFE transcription factors, C-terminal
 IPR030532  Microphthalmia-associated transcription factor
 IPR031867  MiT/TFE transcription factors, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0043473 pigmentation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IC
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood glucose amount , ameliorated
blood glucose increased amount , abnormal
blood decreased amount , abnormal
Show

 ZFA:0000008 brain brain neoplasm occurrence , ameliorated
brain neoplasm increased occurrence , abnormal
brain increased amount , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle functionality , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
pericardium morphology , ameliorated
Show

 ZFA:0000075 spinal cord spinal cord curved , abnormal
Show

 ZFA:0000076 swim bladder swim bladder absent , abnormal
Show

 ZFA:0000107 eye eye iridophore absent , abnormal
eye lacks all parts of type iridophore , abnormal
eye transparent , abnormal
eye lacks parts or has fewer parts of type iridophore , abnormal
Show

 ZFA:0000112 gut gut apical plasma membrane decreased amount , abnormal
Show

 ZFA:0000114 heart heart decreased amount , abnormal
heart edematous , abnormal
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 ZFA:0000123 liver liver has extra parts of type hepatocyte , abnormal
liver decreased size , abnormal
liver cell proliferation decreased process quality , abnormal
liver increased size , abnormal
liver has fewer parts of type hepatocyte , abnormal
liver apical plasma membrane decreased amount , abnormal
liver neoplastic , abnormal
liver hepatocellular carcinoma increased occurrence , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium decreased pigmentation , abnormal
retinal pigmented epithelium unpigmented , abnormal
Show

 ZFA:0000151 pronephros pronephros structure , abnormal
pronephros endosome increased amount , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion decreased amount , abnormal
Show

 ZFA:0000217 inner ear inner ear swollen , abnormal
Show

 ZFA:0000232 otic vesicle lateral protrusion otic vesicle lateral protrusion increased size , abnormal
Show

 ZFA:0000368 integument integument translucent , abnormal
integument melanocyte absent , abnormal
integument iridophore absent , abnormal
Show

 ZFA:0000669 head kidney head kidney T cell decreased amount , abnormal
head kidney hematopoietic cell apoptotic , abnormal
head kidney hematopoietic cell decreased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin has extra parts of type iridophore , abnormal
caudal fin ventral region decreased pigmentation , abnormal
caudal fin melanocyte decreased amount , abnormal
caudal fin ventral region decreased pigmentation , exacerbated
caudal fin melanocyte decreased amount , exacerbated
Show

 ZFA:0001078 thymus thymus decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type melanocyte , abnormal
whole organism lacks all parts of type xanthophore , abnormal
whole organism lacks parts or has fewer parts of type melanoblast , abnormal
whole organism lacks parts or has fewer parts of type melanocyte , abnormal
whole organism Melanin decreased amount , abnormal
whole organism melanoma present , abnormal
whole organism melanoma decreased size , abnormal
whole organism decreased pigmentation , abnormal
whole organism decreased life span , abnormal
whole organism decreased size , abnormal
whole organism neurofibrosarcoma increased amount , abnormal
whole organism neurofibrosarcoma increased amount , ameliorated
whole organism melanoma size , ameliorated
whole organism melanoma increased amount , abnormal
whole organism melanoma decreased amount , abnormal
whole organism neoplasm increased amount , abnormal
whole organism melanoma increased occurrence , abnormal
whole organism neoplastic , abnormal
whole organism neuroblastoma increased occurrence , abnormal
whole organism Lymphoid neoplasms increased occurrence , abnormal
whole organism embryonal rhabdomyosarcoma increased occurrence , abnormal
whole organism decreased length , abnormal
whole organism decreased life span , ameliorated
whole organism sterile , abnormal
whole organism dead , abnormal
whole organism weight , ameliorated
whole organism increased weight , abnormal
Show

 ZFA:0001114 head head melanoma present , abnormal
Show

 ZFA:0001115 trunk trunk iridophore mislocalised , abnormal
trunk dermis lacks all parts of type melanocyte , abnormal
trunk dermis lacks all parts of type xanthophore , abnormal
trunk colorless , abnormal
Show

 ZFA:0001117 post-vent region post-vent region melanoma present , abnormal
post-vent region naevus present , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel filopodium decreased amount , abnormal
Show

 ZFA:0001288 renal glomerulus renal glomerulus malformed , abnormal
renal glomerulus glomerulus vasculature development disrupted , abnormal
renal glomerulus podocyte foot morphology , abnormal
renal glomerulus podocyte decreased amount , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer spatial pattern , abnormal
retinal inner plexiform layer retina layer formation decreased occurrence , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe melanocyte absent , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus pronephric glomerular capillary malformed , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein immature , abnormal
Show

 ZFA:0005220 larval melanophore stripe larval melanophore stripe melanocyte absent , abnormal
Show

 ZFA:0005237 erythroblast erythroblast increased amount , abnormal
Show

 ZFA:0005284 glomerular capillary glomerular capillary imperforate , abnormal
Show

 ZFA:0005285 glomerular basement membrane glomerular basement membrane has fewer parts of type podocyte , abnormal
glomerular basement membrane structure , abnormal
Show

 ZFA:0005312 pronephric capsular space pronephric capsular space dilated , abnormal
pronephric capsular space protein increased amount , abnormal
Show

 ZFA:0005654 blood plasma blood plasma triglyceride amount , ameliorated
blood plasma triglyceride increased amount , abnormal
Show

 ZFA:0005759 visceral fat visceral fat amount , ameliorated
visceral fat increased amount , abnormal
Show

 ZFA:0009090 pigment cell pigment cell irregular spatial pattern , abnormal
pigment cell decreased amount , abnormal
pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte absent , abnormal
melanocyte decreased amount , abnormal
melanocyte irregular spatial pattern , abnormal
melanocyte aplastic , abnormal
melanocyte decreased pigmentation , abnormal
melanocyte decreased branchiness , abnormal
melanocyte neoplastic , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased amount , ameliorated
Show

 ZFA:0009111 hepatocyte hepatocyte necrotic , abnormal
Show

 ZFA:0009198 xanthophore xanthophore decreased amount , abnormal
xanthophore spatial pattern , abnormal
Show

 ZFA:0009199 iridophore iridophore irregular spatial pattern , abnormal
iridophore decreased amount , abnormal
iridophore absent , abnormal
iridophore increased amount , abnormal
iridophore amount , abnormal
iridophore pigmentation process quality , abnormal
Show

 ZFA:0009249 melanoblast melanoblast decreased amount , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell neuron projection extension process quality , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte hemoglobin complex decreased amount , abnormal
nucleate erythrocyte hemoglobin complex normal amount , ameliorated
Show

 ZFA:0009285 podocyte podocyte decreased distribution , abnormal
podocyte decreased amount , abnormal
podocyte structure , abnormal
podocyte apoptotic process increased process quality , abnormal
podocyte detached from pronephric glomerulus , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron anterograde axonal transport of mitochondrion process quality , abnormal
dopaminergic neuron retrograde axonal transport of mitochondrion process quality , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell neuron projection terminus spatial pattern , abnormal
Show

 ZFA:0009374 kidney epithelial cell kidney epithelial cell apical plasma membrane decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex






 

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contact: otassy@igbmc.fr